AJP - Heart Calcium Transients and Cell-Sarcomere
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 279: H1029-H1035, 2000;
0363-6135/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (14)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schwanke, U.
Right arrow Articles by Schipke, J. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schwanke, U.
Right arrow Articles by Schipke, J. D.
Vol. 279, Issue 3, H1029-H1035, September 2000

Heterogeneity of local myocardial flow and oxidative metabolism

Uwe Schwanke1, Andreas Deussen2, Gerd Heusch1, and Jochen D. Schipke3

1 Department of Pathophysiology, University of Essen Medical School, D-45122 Essen; 2 Institute for Physiology, Department of Medical Science Carl Gustav Carus, Dresden Technical University, D-01307 Dresden; and 3 Department of Surgery, Research Group of Experimental Surgery, Heinrich-Heine-University, D-40225 Düsseldorf, Germany

In mammalian hearts, local myocardial flow (LMF) varies between 20 and 200% of the mean. It is not clear whether oxidative metabolism has a similar degree of heterogeneity. Therefore, we investigated the relation between LMF and local oxidative metabolism in isolated rabbit hearts. Buffer oxygenation with 18O2 resulted in labeled myocardial oxidation water (H218O). In four hearts, myocardial oxygen consumption (MVO2) was calculated from the H218O production and compared with that calculated according to Fick. In eight additional hearts, LMF was measured using microspheres. Coronary venous H218O kinetics and local H218O residues were determined and analyzed by mathematical modeling. MVO2 recovery from H218O was >93% compared with that according to Fick. LMF ranged from 1.91 to 11.24 ml · min-1 · g-1, and local H218O residue ranged from 0.41 to 1.04 µmol/g. Both variables correlated (r = 0.62, n = 64, P < 0.001). Measurements in nine hearts were fitted by modeling using capillary permeability-surface area products (PSc) from 2 to 10 ml · min-1 · g-1. With flow-proportional PSc, a 3.33-fold difference in LMF was associated with a 6.45-fold difference in local MVO2. Both LMF and local oxidative metabolism are spatially heterogeneous, and they correlate to one another.

myocardial oxidation water; oxygen-18 labeling; modeling


This article has been cited by other articles:


Home page
 J Am Coll CardiolHome page
W. Y. Vanagt, R. N. Cornelussen, T. C. Baynham, A. Van Hunnik, Q. P. Poulina, F. Babiker, J. Spinelli, T. Delhaas, and F. W. Prinzen
Pacing-Induced Dyssynchrony During Early Reperfusion Reduces Infarct Size
J. Am. Coll. Cardiol., May 1, 2007; 49(17): 1813 - 1819.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. Matsumoto, T. Asano, K. Mano, H. Tachibana, M. Todoh, M. Tanaka, and F. Kajiya
Regional myocardial perfusion under exchange transfusion with liposomal hemoglobin: in vivo and in vitro studies using rat hearts
Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1909 - H1914.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. J. C. Alders, A. B. J. Groeneveld, F. J. J. de Kanter, and J. H. G. M. van Beek
Myocardial O2 consumption in porcine left ventricle is heterogeneously distributed in parallel to heterogeneous O2 delivery
Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1353 - H1361.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. Matsumoto, H. Tachibana, T. Asano, M. Takemoto, Y. Ogasawara, K. Umetani, and F. Kajiya
Pattern differences between distributions of microregional myocardial flows in crystalloid- and blood-perfused rat hearts
Am J Physiol Heart Circ Physiol, April 1, 2004; 286(4): H1331 - H1338.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. C. Marshall, P. Powers-Risius, B. W. Reutter, A. M. Schustz, C. Kuo, M. K. Huesman, and R. H. Huesman
Flow heterogeneity following global no-flow ischemia in isolated rabbit heart
Am J Physiol Heart Circ Physiol, February 1, 2003; 284(2): H654 - H667.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
U. K. M. Decking
Spatial Heterogeneity in the Heart: Recent Insights and Open Questions
Physiology, December 1, 2002; 17(6): 246 - 250.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. Berlin, K. E. Challoner, and R. D. Woodson
Low-O2 affinity erythrocytes improve performance of ischemic myocardium
J Appl Physiol, March 1, 2002; 92(3): 1267 - 1276.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. C. Chatham, C. Des Rosiers, and J. R. Forder
Evidence of separate pathways for lactate uptake and release by the perfused rat heart
Am J Physiol Endocrinol Metab, October 1, 2001; 281(4): E794 - E802.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online