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Am J Physiol Heart Circ Physiol 279: H1274-H1282, 2000;
0363-6135/00 $5.00
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Vol. 279, Issue 3, H1274-H1282, September 2000

Effects of hypoxia on pulmonary microvascular volume

Anne V. Clough1,2, Steven T. Haworth3, Wei Ma1, and Christopher A. Dawson2,3,4

1 Department of Mathematics, Statistics and Computer Science, 2 Biomedical Engineering Department, Marquette University, Milwaukee 53201-1881; 3 Department of Physiology, Medical College of Wisconsin, Milwaukee 53226; and 4 Research Service, Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53295

To determine the effects of alveolar hypoxia on pulmonary microvascular volume, X-ray microfocal angiographic images of isolated perfused dog lung lobes were obtained during passage of a bolus of radiopaque contrast medium during both normoxic (alveolar gas, 15% O2, 6% CO2, and 79% N2) and hypoxic (3% O2, 6% CO2, and 91% N2) conditions. Regions of interest (ROIs) over the lobar artery and vein at low magnification and a feeding artery (~500 µm diameter) and the nearby microvasculature (vessels smaller than ~50 µm) at high magnification were identified, and X-ray absorbance vs. time curves were acquired under both conditions from the same ROIs. The total pulmonary vascular volume was calculated from the flow and the mean transit time for the contrast medium passage from the lobar artery to lobar vein. The fractional changes in microvascular volume were determined from the areas under the high-magnification X-ray absorbance curves. Hypoxia decreased lobar volume by 13 ± 3% (SE) and regional microvascular volume by 26 ± 4% (SE). Given the morphometry of the lung vasculature, these results suggest that capillary volume was decreased by hypoxia.

alveolar hypoxia; pulmonary angiography; pulmonary capillaries; pulmonary blood volume; X-ray; serotonin


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