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1 Circulatory Control Laboratory, Department of Physiology, University of Auckland, Auckland, New Zealand; and 2 Department of Physiology, University of Kentucky, Lexington, Kentucky 40536-0084
Blood pressure contains a distinct
low-frequency oscillation often termed the Mayer wave. This oscillation
is caused by the action of the sympathetic nervous system on the
vasculature and results from time delays in the baroreflex feedback
loop for the control of sympathetic nerve activity (SNA) in response to
changes in blood pressure. In this study, we used bilateral renal
denervation to test the hypothesis that it is SNA to the kidney that
contributes a large portion of the vascular resistance associated with
changes in the strength of the slow oscillation in blood pressure. In conscious rabbits, SNA and blood pressure were measured during hemorrhage (blood withdrawal at 1.35 ml · min
1 · kg1 for 20 min). Spectral analysis identified a strong increase in power at 0.3 Hz
in SNA and blood pressure in the initial compensatory phase of
hemorrhage before blood pressure started to fall. However, in a
separate group of renal denervated rabbits, although the power of the
0.3-Hz oscillation under control conditions in blood pressure was
similar, it was not altered during hemorrhage. Wavelet analysis
revealed the development of low-frequency oscillations at 0.1 Hz in
both intact and denervated animals. In conclusion, we propose that
changes in the strength of the oscillation at 0.3 Hz in arterial
pressure during hemorrhage are primarily mediated by sympathetic
activity directed to the kidney.
conscious rabbit; sympathetic nervous system; spectral analysis; renal denervation
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