AJP - Heart Calcium Transients and Cell-Sarcomere
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 279: H946-H951, 2000;
0363-6135/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (12)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wagner, E. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wagner, E. M.
Vol. 279, Issue 3, H946-H951, September 2000

TNF-alpha induced bronchial vasoconstriction

Elizabeth M. Wagner

Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21224

The pro-inflammatory characteristics of tumor necrosis factor-alpha (TNF-alpha ) have been extensively characterized in in vitro systems. Furthermore, this cytokine has been shown to play a pivotal role in airways inflammation in asthma. Since the airway vasculature also performs an essential function in inflammatory cell transit to the airways, experiments were performed to determine the effects of TNF-alpha on bronchial vascular resistance (BVR). In anesthetized, ventilated sheep, the bronchial artery (BA) was cannulated and perfused with autologous blood. BVR was defined as inflow pressure/flow and averaged 6.3 ± 0.2 mmHg · ml-1 · min-1 (±SE) for the 25 sheep studied. Recombinant human TNF-alpha (10 µg for 20 or 40 min) infused directly into the BA resulted in a significant decrease in BVR to 87% of baseline (P < 0.05). This vasodilation was followed by a reversal of tone by 120 min and a sustained increase in BVR to 126% of baseline (P < 0.05). Since others have shown TNF-alpha caused coronary vasoconstriction through endothelial release of endothelin-1 (ET-1), an ET-1 antagonist was used to block bronchial vasoconstriction. BQ-123, a selective ETA receptor antagonist, was delivered to the bronchial vasculature prior to TNF-alpha challenge. Attenuation of bronchial vasoconstriction was observed at 120 min (P < 0.03). Thus TNF-alpha causes bronchial vasoconstriction by the secondary release of ET-1. Although TNF-alpha exerts pro-inflammatory actions on most cells of the airways, vasoactive properties of this cytokine likely further contribute to the inflammatory status of the airways.

bronchial artery; tumor necrosis factor-alpha ; endothelin-1; airways resistance; inflammation; sheep


This article has been cited by other articles:


Home page
 Am. J. Physiol. Cell Physiol.Home page
S. Y. Cheranov and J. H. Jaggar
TNF-{alpha} dilates cerebral arteries via NAD(P)H oxidase-dependent Ca2+ spark activation
Am J Physiol Cell Physiol, April 1, 2006; 290(4): C964 - C971.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
G. Horvath and A. Wanner
Inhaled corticosteroids: effects on the airway vasculature in bronchial asthma
Eur. Respir. J., January 1, 2006; 27(1): 172 - 187.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
E. Vila and M. Salaices
Cytokines and vascular reactivity in resistance arteries
Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1016 - H1021.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
D. K. Meyerholz, B. Grubor, J. M. Gallup, H. D. Lehmkuhl, R. D. Anderson, T. Lazic, and M. R. Ackermann
Adenovirus-Mediated Gene Therapy Enhances Parainfluenza Virus 3 Infection in Neonatal Lambs
J. Clin. Microbiol., October 1, 2004; 42(10): 4780 - 4787.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Moldobaeva and E. M. Wagner
Angiotensin-converting enzyme activity in ovine bronchial vasculature
J Appl Physiol, December 1, 2003; 95(6): 2278 - 2284.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online