AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 279: H1571-H1578, 2000;
0363-6135/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (17)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Keith, I. M.
Right arrow Articles by Ekman, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Keith, I. M.
Right arrow Articles by Ekman, R.
Vol. 279, Issue 4, H1571-H1578, October 2000

Three-week neonatal hypoxia reduces blood CGRP and causes persistent pulmonary hypertension in rats

I. M. Keith1, S. Tjen-A-Looi1, H. Kraiczi2, and R. Ekman2

1 Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706; and 2 Section of Experimental Neuroscience, Institute of Clinical Neuroscience, University of Göteborg, Mölndal's Hospital, S-43180 Mölndal, Sweden

To increase understanding of persistent pulmonary hypertension, we examined chronic pulmonary effects of hypoxia at birth and their relationships with immunoreactive levels of the potent vasodilator, calcitonin gene-related peptide (CGRP). Rats were born in 10% hypobaric hypoxia, where they remained for 1-2 days, or in 15% hypoxia, where they remained for 21 days. All were then reared in normoxia for 3 mo followed by reexposure to 10% hypoxia for 7 days (Hright-arrowH) or continued normoxia (Hright-arrowN); age-matched normoxic rats were hypoxic for the last 7 days (Nright-arrowH) or normoxic throughout (Nright-arrowN). Results are as follows. Pulmonary arterial pressure (PPA) in 10% Hright-arrowN rats was normal at the end of the experiment (13 wk), but in rats reexposed to hypoxia (Hright-arrowH), pressure rose to 19% above Nright-arrowH controls. In 15% Hright-arrowN rats, PPA remained high, similar to that of Nright-arrowH rats, and increased further by 40% on reexposure (Hright-arrowH). Medial thickness of small pulmonary arteries in 10% Hright-arrowH rats also increased by 40% over Nright-arrowH controls and was equally high in 15% Hright-arrowN and Hright-arrowH rats. In Nright-arrowH rats from both experiments, right ventricular hypertrophy index (RVH) was increased after hypoxia at 15-16 wk. Also, in the 15% study, RVH remained elevated in Hright-arrowN rats and increased in Hright-arrowH rats by 19% above Nright-arrowH controls. Blood CGRP was reduced by neonate and adult hypoxia, and hypoxic reexposure (Hright-arrowH) further lowered blood CGRP in the 15% but not 10% study. Declining left ventricular blood CGRP correlated highly with logarithmically increasing PPA in the 15% study (r = -0.81, P = 0.000). In conclusion, 1) short perinatal exposure to 10% O2 exacerbated pulmonary hypertension with hypoxia later in life, 2) 15% O2 at birth and for 21 days caused persistent pulmonary hypertension and exacerbation with reexposure, and 3) PPA correlated highly with declining blood CGRP levels in the 15% study.

hypoxic sensitization; persistent hyperventilation; right ventricular hypertrophy; calcitonin gene-related peptide


This article has been cited by other articles:


Home page
 Ann. Thorac. Surg.Home page
Q. Zhao, Z. Liu, Z. Wang, C. Yang, J. Liu, and J. Lu
Effect of Prepro-Calcitonin Gene-Related Peptide Expressing Endothelial Progenitor Cells on Pulmonary Hypertension
Ann. Thorac. Surg., August 1, 2007; 84(2): 544 - 552.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. Kantores, P. J. McNamara, L. Teixeira, D. Engelberts, P. Murthy, B. P. Kavanagh, and R. P. Jankov
Therapeutic hypercapnia prevents chronic hypoxia-induced pulmonary hypertension in the newborn rat
Am J Physiol Lung Cell Mol Physiol, November 1, 2006; 291(5): L912 - L922.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
W. Deng, T. J. Bivalacqua, N. N. Chattergoon, J. R. Jeter Jr., and P. J. Kadowitz
Engineering Ex Vivo-Expanded Marrow Stromal Cells to Secrete Calcitonin Gene-Related Peptide Using Adenoviral Vector
Stem Cells, December 1, 2004; 22(7): 1279 - 1291.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. Villamor, C. G. A. Kessels, K. Ruijtenbeek, R. J. van Suylen, J. Belik, J. G. R. De Mey, and C. E. Blanco
Chronic in ovo hypoxia decreases pulmonary arterial contractile reactivity and induces biventricular cardiac enlargement in the chicken embryo
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2004; 287(3): R642 - R651.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
S. D. Brain and A. D. Grant
Vascular Actions of Calcitonin Gene-Related Peptide and Adrenomedullin
Physiol Rev, July 1, 2004; 84(3): 903 - 934.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
V. Hampl, J. Bibova, I. Ostadalova, V. Povysilova, and J. Herget
Gender differences in the long-term effects of perinatal hypoxia on pulmonary circulation in rats
Am J Physiol Lung Cell Mol Physiol, August 1, 2003; 285(2): L386 - L392.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
X. Qing and I. M. Keith
Targeted blocking of gene expression for CGRP receptors elevates pulmonary artery pressure in hypoxic rats
Am J Physiol Lung Cell Mol Physiol, July 1, 2003; 285(1): L86 - L96.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online