| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Health and Kinesiology, Sam Houston State University, Huntsville 77341; and 2 Department of Health and Kinesiology, Texas A&M University, and 3 Department of Medical Physiology, Texas A&M Health Sciences Center, College Station, Texas 77843
At the onset of dynamic exercise, muscle blood flow increases within 1-2 s. It has been postulated that local vasodilatory agents produced by the vascular endothelium or the muscle itself contribute to this response. We hypothesized that only vasodilators that act directly on the vascular smooth muscle could produce vasodilation of skeletal muscle arterioles in <2 s. To test this hypothesis, we determined the time course of the vasodilatory response of isolated skeletal muscle arterioles to direct application of potassium chloride, adenosine, acetylcholine, and sodium nitroprusside. Soleus and gastrocnemius muscles were dissected from the hindlimbs of male Sprague-Dawley rats. First-order arterioles (100-200 µm) were isolated, cannulated on micropipettes, and pressurized to 60 cmH2O in an organ bath. Vasodilatory agents were added directly to the bath, and diameter responses of the arterioles were recorded in real time on a videotape recorder. Frame-by-frame analysis of the diameter responses indicated that none of the vasodilator agents tested produced significant diameter increases in <4 s in either soleus or gastrocnemius muscle arterioles. These results indicate that, although these local vasodilators produce significant vasodilation of skeletal muscle resistance arterioles, these responses are not rapid enough (within 1-2 s) to contribute to the initiation of the exercise hyperemic response at the onset of dynamic exercise.
exercise hyperemia; acetylcholine; potassium chloride; adenosine; sodium nitroprusside
This article has been cited by other articles:
|
|
 |
|
  A. J. Harper, L. F. Ferreira, B. J. Lutjemeier, D. K. Townsend, and T. J. Barstow Matching of blood flow to metabolic rate during recovery from moderate exercise in humans Exp Physiol, October 1, 2008; 93(10): 1118 - 1125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. J Dietze and E. J Henriksen Review: Angiotensin-converting enzyme in skeletal muscle: sentinel of blood pressure control and glucose homeostasis Journal of Renin-Angiotensin-Aldosterone System, June 1, 2008; 9(2): 75 - 88. [Abstract] [PDF]
|
|
|
|
 |
|
 W.-C. Wu, J. Wang, J. A. Detre, F. W. Wehrli, E. Mohler 3rd, S. J. Ratcliffe, and T. F. Floyd Hyperemic flow heterogeneity within the calf, foot, and forearm measured with continuous arterial spin labeling MRI Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2129 - H2136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. S. Kirby and R. E. Carlson Potassium, contracting myocytes and rapid vasodilatation: peaking more than just our interest? J. Physiol., January 15, 2008; 586(2): 315 - 317. [Full Text] [PDF]
|
|
|
|
|
|
B. S. Kirby, R. E. Carlson, R. R. Markwald, W. F. Voyles, and F. A. Dinenno Mechanical influences on skeletal muscle vascular tone in humans: insight into contraction-induced rapid vasodilatation J. Physiol., September 15, 2007; 583(3): 861 - 874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. Clifford Skeletal muscle vasodilatation at the onset of exercise J. Physiol., September 15, 2007; 583(3): 825 - 833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Rogers, N. R. Saunders, K. E. Pyke, and M. E. Tschakovsky Rapid vasoregulatory mechanisms in exercising human skeletal muscle: dynamic response to repeated changes in contraction intensity Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1065 - H1073. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Joyner Exercise hyperemia: waiting for the reductionists? Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1032 - H1033. [Full Text] [PDF]
|
|
|
|
|
|
A. J. Harper, L. F. Ferreira, B. J. Lutjemeier, D. K. Townsend, and T. J. Barstow Human femoral artery and estimated muscle capillary blood flow kinetics following the onset of exercise Exp Physiol, July 1, 2006; 91(4): 661 - 671. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Sheriff, P. S. Clifford, J. J. Hamann, Z. Valic, and J. B. Buckwalter Point: The muscle pump raises muscle blood flow during locomotion J Appl Physiol, July 1, 2005; 99(1): 371 - 375. [Full Text] [PDF]
|
|
|
|
|
|
D. W. Wray, A. J Donato, A. Uberoi, J. P Merlone, and R. S Richardson Onset exercise hyperaemia in humans: partitioning the contributors J. Physiol., June 15, 2005; 565(3): 1053 - 1060. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. F. Ferreira, D. K. Townsend, B. J. Lutjemeier, and T. J. Barstow Muscle capillary blood flow kinetics estimated from pulmonary O2 uptake and near-infrared spectroscopy J Appl Physiol, May 1, 2005; 98(5): 1820 - 1828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Lutjemeier, A. Miura, B. W. Scheuermann, S. Koga, D. K. Townsend, and T. J. Barstow Muscle contraction-blood flow interactions during upright knee extension exercise in humans J Appl Physiol, April 1, 2005; 98(4): 1575 - 1583. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Valic, J. B. Buckwalter, and P. S. Clifford Muscle blood flow response to contraction: influence of venous pressure J Appl Physiol, January 1, 2005; 98(1): 72 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. R. Saunders, F. A. Dinenno, K. E. Pyke, A. M. Rogers, and M. E. Tschakovsky Impact of combined NO and PG blockade on rapid vasodilation in a forearm mild-to-moderate exercise transition in humans Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H214 - H220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. R. Saunders and M. E. Tschakovsky Evidence for a rapid vasodilatory contribution to immediate hyperemia in rest-to-mild and mild-to-moderate forearm exercise transitions in humans J Appl Physiol, September 1, 2004; 97(3): 1143 - 1151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Tschakovsky and D. D. Sheriff Immediate exercise hyperemia: contributions of the muscle pump vs. rapid vasodilation J Appl Physiol, August 1, 2004; 97(2): 739 - 747. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. Clifford and Y. Hellsten Vasodilatory mechanisms in contracting skeletal muscle J Appl Physiol, July 1, 2004; 97(1): 393 - 403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. DeLorey, J. M. Kowalchuk, and D. H. Paterson Effect of age on O2 uptake kinetics and the adaptation of muscle deoxygenation at the onset of moderate-intensity cycling exercise J Appl Physiol, July 1, 2004; 97(1): 165 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Hamann, J. B. Buckwalter, and P. S. Clifford Vasodilatation is obligatory for contraction-induced hyperaemia in canine skeletal muscle J. Physiol., June 15, 2004; 557(3): 1013 - 1020. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Hamann, J. B. Buckwalter, P. S. Clifford, and J. K. Shoemaker Is the blood flow response to a single contraction determined by work performed? J Appl Physiol, June 1, 2004; 96(6): 2146 - 2152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. McDonough, B. J. Behnke, T. I. Musch, and D. C. Poole Recovery of microvascular PO2 during the exercise off-transient in muscles of different fiber type J Appl Physiol, March 1, 2004; 96(3): 1039 - 1044. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Tschakovsky, A. M. Rogers, K. E. Pyke, N. R. Saunders, N. Glenn, S. J. Lee, T. Weissgerber, and E. M. Dwyer Immediate exercise hyperemia in humans is contraction intensity dependent: evidence for rapid vasodilation J Appl Physiol, February 1, 2004; 96(2): 639 - 644. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B.J Behnke, M.D Delp, P McDonough, S.A Spier, D.C Poole, and T.I Musch Effects of chronic heart failure on microvascular oxygen exchange dynamics in muscles of contrasting fiber type Cardiovasc Res, February 1, 2004; 61(2): 325 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Sheriff Muscle pump function during locomotion: mechanical coupling of stride frequency and muscle blood flow Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2185 - H2191. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J Behnke, P. McDonough, D. J Padilla, T. I Musch, and D. C Poole Oxygen exchange profile in rat muscles of contrasting fibre types J. Physiol., June 1, 2003; 549(2): 597 - 605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Sheriff and T. M. Zidon Delay of muscle vasodilation to changes in work rate (treadmill grade) during locomotion J Appl Physiol, May 1, 2003; 94(5): 1903 - 1909. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. McAllister Endothelium-dependent vasodilation in different rat hindlimb skeletal muscles J Appl Physiol, May 1, 2003; 94(5): 1777 - 1784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Aaker and M. H. Laughlin Differential adenosine sensitivity of diaphragm and skeletal muscle arterioles J Appl Physiol, September 1, 2002; 93(3): 848 - 856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. DeLorey, S. S. Wang, and J. K. Shoemaker Evidence for sympatholysis at the onset of forearm exercise J Appl Physiol, August 1, 2002; 93(2): 555 - 560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Valic, J. S. Naik, S. B. Ruble, J. B. Buckwalter, and P. S. Clifford Elevation in resting blood flow attenuates exercise hyperemia J Appl Physiol, July 1, 2002; 93(1): 134 - 140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Kindig, T. E. Richardson, and D. C. Poole Skeletal muscle capillary hemodynamics from rest to contractions: implications for oxygen transfer J Appl Physiol, June 1, 2002; 92(6): 2513 - 2520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Sheriff and A. L. Hakeman Role of speed vs. grade in relation to muscle pump function at locomotion onset J Appl Physiol, July 1, 2001; 91(1): 269 - 276. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
