AJP - Heart Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 279: H1922-H1930, 2000;
0363-6135/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (16)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sielenkämper, A. W.
Right arrow Articles by Sibbald, W. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sielenkämper, A. W.
Right arrow Articles by Sibbald, W. J.
Vol. 279, Issue 4, H1922-H1930, October 2000

Diaspirin cross-linked Hb and norepinephrine prevent the sepsis-induced increase in critical O2 delivery

Andreas W. Sielenkämper, Pei Yu, Otto Eichelbrönner, Tammy MacDonald, Claudio M. Martin, Ian H. Chin-Yee, and William J. Sibbald

The A. C. Burton Vascular Biology Laboratory, Victoria Hospital Research Institute, and The University of Western Ontario, London, Ontario, Canada N6A 4G5

We hypothesized that support of arterial perfusion pressure with diaspirin cross-linked Hb (DCLHb) would prevent the sepsis-induced attenuation in the systemic O2 delivery-O2 uptake relationship. Awake septic rats were treated with a chronic infusion of DCLHb or a reference treatment [norepinephrine (NE)] to increase mean arterial pressure by 10-20% over 18 h. Septic and sham control groups received normal saline. Isovolemic hemodilution to create anemic hypoxia was then performed in a metabolic box during continuous measurement of systemic O2 uptake. O2 delivery was calculated from hemodynamic variables, and the critical point of O2 delivery (DO2 crit) was determined using piecewise regression analysis of the O2 delivery-O2 uptake relationship. Sepsis increased DO2 crit from 4.99 ± 0.17 to 6.69 ± 0.42 ml · min-1 · 100 g-1 (P < 0.01), while O2 extraction capacity was decreased (P < 0.05). DCLHb and NE infusion prevented the sepsis-induced increase in DO2 crit [4.56 ± 0.42 ml · min-1 · 100 g-1 (P < 0.01) and 5.04 ± 0.56 ml · min-1 · 100 g-1 (P < 0.05), respectively]. This was explained by a 59% increase in O2 extraction capacity in the DCLHb group compared with septic controls (P < 0.05), whereas NE treatment decreased systemic O2 uptake in anemic hypoxia (1.51 ± 0.08 vs. 1.87 ± 0.1 ml · min-1 · 100 g-1 in septic controls, P < 0.05). We conclude that DCLHb ameliorated O2 extraction capacity in the septic microcirculation, whereas NE decreased the metabolic demands of the tissues.

blood substitute; anemic hypoxia; cardiovascular; rat


This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
G. M. T. Hare, K. M. Hum, S. Y. Kim, A. Barr, A. J. Baker, and C. D. Mazer
Increased Cerebral Tissue Oxygen Tension After Extensive Hemodilution with a Hemoglobin-Based Oxygen Carrier
Anesth. Analg., August 1, 2004; 99(2): 528 - 535.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
Y. Morita, I. Chin-Yee, P. Yu, W. J. Sibbald, and C. M. Martin
Critical Oxygen Delivery in Conscious Septic Rats under Stagnant or Anemic Hypoxia
Am. J. Respir. Crit. Care Med., March 15, 2003; 167(6): 868 - 872.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
O. Eichelbronner, M. D'Almeida, A. Sielenkamper, W. J. Sibbald, and I. H. Chin-Yee
Increasing P50 does not improve DO2CRIT or systemic VO2 in severe anemia
Am J Physiol Heart Circ Physiol, July 1, 2002; 283(1): H92 - H101.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online