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Am J Physiol Heart Circ Physiol 279: H2062-H2067, 2000;
0363-6135/00 $5.00
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Vol. 279, Issue 5, H2062-H2067, November 2000

Genetic mapping of quantitative trait loci influencing left ventricular mass in rats

Yasuyuki Tsujita1, Naoharu Iwai2, Shinji Tamaki1, Yasuyuki Nakamura1, Masato Nishimura3, and Masahiko Kinoshita1

1 First Department of Internal Medicine, Shiga University of Medical Science, Otsu 520-2192; 2 Research Institute, National Cardiovascular Center, Suita 565-8565; and 3 Department of Clinical and Laboratory Medicine, Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan

High blood pressure is the leading cause of left ventricular hypertrophy (LVH); however, not all hypertensive patients develop LVH. Genetic factors are important in the development of LVH. With the use of F2 male rats from spontaneously hypertensive rats and Lewis rats, we performed a study to identify the quantitative trait loci (QTL) that influence left ventricular mass (LVM). Mean arterial pressure (MAP) was measured by the direct intra-arterial method in conscious animals, and LVM was determined at 24 wk of age. QTL analysis was done using 160 microsatellite markers for a genome-wide scan. Two loci that influenced body weight-adjusted LVM with logarithm of the odds scores >3.4 were found. One locus on chromosome 17 influenced LVM independently of MAP. Another locus on chromosome 7 influenced LVM and MAP. These findings indicate not only the existence of a gene on chromosome 7 that influences LVM in a manner dependent on blood pressure but also the existence of a gene on chromosome 17 that influences LVM independently of blood pressure.

blood pressure; spontaneously hypertensive rats; hypertension; linkage analysis


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