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Department of Pharmacology and Physiology, University of Rochester, Rochester, New York 14642
To investigate the relationship between skeletal
muscle metabolism and arteriolar dilations in the region local to
contracting muscle fibers as well as dilations at remote arteriolar
regions upstream, we used a microelectrode on cremaster muscle of
anesthetized hamsters to stimulate four to five muscle fibers lying
approximately perpendicular to and overlapping a transverse arteriole.
Before, during, and after muscle contraction, we measured the diameter of the arteriole at the site of muscle fiber overlap (local) and at a
remote site ~1,000 µm upstream. Two minutes of 2-, 4-, or 8-Hz
stimulation (5-10 V, 0.4-ms duration) produced a significant dilation locally (8.2 ± 2.0-, 22.5 ± 2.4-, and 30.9 ± 2.1-µm increase, respectively) and at the remote site (4.2 ± 0.8, 11.0 ± 1.1, and 18.9 ± 2.7 µm, respectively). Muscle
contraction at 4 Hz initiated a remote dilation that was unaffected by
15-min micropipette application of either 2 µM tetrodotoxin, 0.07%
halothane, or 40 µM 18-
-glycyrrhetinic acid between the local and
upstream site. Therefore, at the arteriolar level, muscle contraction
initiates a robust remote dilation that does not appear to be
transmitted via perivascular nerves or gap junctions.
cell coupling; microcirculation; exercise; blood flow; metabolic coupling
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