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Am J Physiol Heart Circ Physiol 279: H2295-H2302, 2000;
0363-6135/00 $5.00
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Vol. 279, Issue 5, H2295-H2302, November 2000

Microvascular flow and tissue PO2 in skeletal muscle of chronic reduced renal mass hypertensive rats

Julian H. Lombard1, Jefferson C. Frisbee1, Andrew S. Greene1, Antal G. Hudetz2, Richard J. Roman1, and Peter J. Tonellato1,3

Departments of 1 Physiology and 2 Anesthesiology, Medical College of Wisconsin, Milwaukee, 53226, and 3 Department of Mathematics, Statistics, and Computer Science, Marquette University, Milwaukee, Wisconsin 53233

This study determined whether arteriolar blood flow, capillary red blood cell (RBC) velocity, capillary hematocrit (Hctcap), and tissue PO2 are altered in cremaster muscles of rats with chronic reduced renal mass hypertension (RRM-HT) relative to normotensive rats on high- or low-salt (NT-HS vs. NT-LS) diet. The blood flow in first- through third-order arterioles was not different between NT and HT rats, either at rest or during maximal relaxation of the vessels with 10-4 M adenosine. Capillary RBC velocity was similar between the groups at rest but was elevated in RRM-HT and NT-HS rats during adenosine superfusion. Hctcap was reduced at rest in RRM-HT and NT-HS rats compared with NT-LS and was reduced in RRM-HT rats during adenosine-induced dilation. Tissue PO2 was reduced in RRM-HT and NT-HS rats compared with NT-LS rats during control conditions and was lower in RRM-HT than in NT-LS rats during adenosine-induced dilation. These results indicate that both RRM-HT and chronic exposure of normotensive rats to a high-salt diet lead to reduced tissue oxygenation, despite the maintenance of normal arteriolar blood flow.

renal hypertension; microcirculation; rarefaction; autoregulation; hemodynamics; reduced renal mass hypertension; microvascular hematocrit; tissue oxygenation


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