| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Section of Cardiovascular Sciences, Department of Medicine, Baylor College of Medicine, Houston 77030; 2 Indus Instruments, Houston, Texas 77058; and 3 Department of Pharmacology, Berlex Biosciences, Richmond, California 94804
Apolipoprotein E-knockout (ApoE-KO) mice develop advanced
atherosclerotic lesions by 1 yr of age and have been well characterized pathologically and morphologically, but little is known regarding their
cardiovascular physiology and hemodynamics. We used noninvasive Doppler
ultrasound to measure aortic and mitral blood velocity and aortic
pulse-wave velocity in 13-mo-old ApoE-KO and wild-type (WT) mice
anesthetized with isoflurane. In other mice from the same colony, we
measured systolic blood pressure, body weight, heart weight,
cholesterol, and hematocrit. Heart rate and blood pressure were
comparable (P = not significant) between ApoE-KO and WT
mice, but significant decreases (P < 0.001) were found in body weight (
22%) and hematocrit (11%), and significant
increases were found in heart weight (+23%), aortic velocity (+60%),
mitral velocity (+81%) (all P < 0.001), and
pulse-wave velocity (+13%, P < 0.05). We also found
inflections in the aortic arch velocity signal consistent with enhanced
peripheral wave reflection. Thus ApoE-KO mice have phenotypic
alterations in indexes of peripheral vascular resistance and compliance
and significantly elevated cardiac outflow velocities and heart
weight-to-body weight ratios.
atherosclerosis; cardiac output; hypertrophy; ultrasonics
This article has been cited by other articles:
|
|
 |
|
  S. Ryoo, G. Gupta, A. Benjo, H. K. Lim, A. Camara, G. Sikka, H. K. Lim, J. Sohi, L. Santhanam, K. Soucy, et al. Endothelial Arginase II: A Novel Target for the Treatment of Atherosclerosis Circ. Res., April 25, 2008; 102(8): 923 - 932. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Fitch, J. C. Rutledge, Y.-X. Wang, A. F. Powers, J.-L. Tseng, T. Clary, and G. M. Rubanyi Synergistic effect of angiotensin II and nitric oxide synthase inhibitor in increasing aortic stiffness in mice Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1190 - H1198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Dworschak, L. V. d'Uscio, D. Breukelmann, and J. D. Hannon Increased tolerance to hypoxic metabolic inhibition and reoxygenation of cardiomyocytes from apolipoprotein E-deficient mice Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H160 - H167. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-X. Wang, B. Martin-McNulty, V. da Cunha, J. Vincelette, X. Lu, Q. Feng, M. Halks-Miller, M. Mahmoudi, M. Schroeder, B. Subramanyam, et al. Fasudil, a Rho-Kinase Inhibitor, Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm in Apolipoprotein E-Deficient Mice by Inhibiting Apoptosis and Proteolysis Circulation, May 3, 2005; 111(17): 2219 - 2226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Hartley, A. K. Reddy, S. Madala, M. L. Entman, L. H. Michael, and G. E. Taffet Noninvasive ultrasonic measurement of arterial wall motion in mice Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1426 - H1432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-H. Li, A. K. Reddy, L. N. Ochoa, T. T. Pham, C. J. Hartley, L. H. Michael, M. L. Entman, and G. E. Taffet Effect of Age on Peripheral Vascular Response to Transverse Aortic Banding in Mice J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2003; 58(10): B895 - 899. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Reddy, Y.-H. Li, T. T. Pham, L. N. Ochoa, M. T. Trevino, C. J. Hartley, L. H. Michael, M. L. Entman, and G. E. Taffet Measurement of aortic input impedance in mice: effects of age on aortic stiffness Am J Physiol Heart Circ Physiol, October 1, 2003; 285(4): H1464 - H1470. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-Q. Zhou, F. S. Foster, R. Parkes, and S. L. Adamson Developmental changes in left and right ventricular diastolic filling patterns in mice Am J Physiol Heart Circ Physiol, October 1, 2003; 285(4): H1563 - H1575. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Bleasdale, K. H. Parker, and C. J. H. Jones Chasing the wave. Unfashionable but important new concepts in arterial wave travel Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H1879 - H1885. [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Alexander, J. W. Knowles, T. Nishikimi, and N. Maeda Increased Atherosclerosis and Smooth Muscle Cell Hypertrophy in Natriuretic Peptide Receptor A-/-Apolipoprotein E-/- Mice Arterioscler Thromb Vasc Biol, June 1, 2003; 23(6): 1077 - 1082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gervais, S. Pons, A. Nicoletti, C. Cosson, J.-F. Giudicelli, and C. Richer Fluvastatin Prevents Renal Dysfunction and Vascular NO Deficit in Apolipoprotein E-Deficient Mice Arterioscler Thromb Vasc Biol, February 1, 2003; 23(2): 183 - 189. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Tham, B. Martin-McNulty, Y.-X. Wang, V. Da Cunha, D. W. Wilson, C. N. Athanassious, A. F. Powers, M. E. Sullivan, and J. C. Rutledge Angiotensin II injures the arterial wall causing increased aortic stiffening in apolipoprotein E-deficient mice Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2002; 283(6): R1442 - R1449. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
