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Am J Physiol Heart Circ Physiol 279: H2464-H2476, 2000;
0363-6135/00 $5.00
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Vol. 279, Issue 5, H2464-H2476, November 2000

Normal values of regional left ventricular endocardial motion: multicenter color kinesis study

Victor Mor-Avi1, Kirk Spencer1, John Gorcsan2, Anthony Demaria3, Thomas Kimball4, Mark Monaghan5, Julio Perez6, Jing Ping Sun7, Lynn Weinert1, James Bednarz1, Keith Collins1, Kathy Edelman2, Oi Ling Kwan3, Betty Glascock4, Jane Hancock5, Chris Baumann6, James Thomas7, and Roberto Lang1

1 The University of Chicago, Chicago, Illinois 60637; 2 University of Pittsburgh, Pittsburgh, Pennsylvania 15261; 3 University of California, San Diego, California 92103; 4 Children's Hospital, Cincinnati 45229, 7 Cleveland Clinic Foundation, Cleveland, Ohio 44195; 5 King's College, London, United Kingdom WC2R 2LS; and 6 Washington University, St. Louis, Missouri 63110

Our goal was to establish normal values for quantitative color kinesis indexes of left ventricular (LV) wall motion over a wide range of ages, which are required for objective diagnosis of regional systolic and diastolic dysfunction. Color-encoded images were obtained in 194 normal subjects (95 males, 99 females, age 2 mo to 79 yr) in four standard views. Quantitative indexes of magnitude and timing of systolic and diastolic function were studied for age- and gender-related differences. Normal limits of all ejection and filling indexes were in a narrow range (<= 25% of the mean), with no major gender-related differences. Despite invariable ejection fractions, both peak filling and ejection rates decreased with age (30 and 20%, correspondingly) with a concomitant increase in mean filling and ejection times, resulting in five- and twofold increases in the late to early filling and ejection ratios, correspondingly. Diastolic asynchrony increased with age (from 4.7 ± 2.0 to 6.4 ± 3.2 from the 2nd to 7th decade). The normal values of color kinesis indexes should allow objective detection of regional LV systolic and diastolic dysfunction.

echocardiography; ultrasound imaging; ventricular function; wall motion


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