| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Physiopathologie des Canaux Ioniques, Institut de Génétique Humaine-Centre National de la Recherche Scientifique (CNRS) UPR 1142, 34396 Montpellier cedex 05; and 2 Biologie des Neurones Endocrines, Centre CNRS-INSERM de Pharmacologie Expérimentale-CNRS UMR 5101, 34094 Montpellier cedex 05, France
T-type
Ca2+ channels have been suggested to play a role in
cardiac automaticity, cell growth, and cardiovascular remodeling. Although three genes encoding for a T-type Ca2+ channel
have been identified, the nature of the isoform(s) supporting the
cardiac T-type Ca2+ current (ICa,T)
has not yet been determined. We describe the postnatal evolution of
ICa,T density in freshly dissociated rat atrial
and ventricular myocytes and its functional properties at peak current
density in young atrial myocytes. ICa,T displays a classical low activation threshold, rapid inactivation kinetics, negative steady-state inactivation, slow deactivation, and the presence
of a window current. Interestingly, ICa,T is
poorly sensitive to Ni2+ and insensitive to R-type current
toxin SNX-482. RT-PCR experiments and comparison of functional
properties with recombinant Ca2+ channel subtypes suggest
that neonatal ICa,T is related to the 
1G-subunit. Atrial natriuretic factor (ANF) secretion
was measured using peptide radioimmunoassays in atrial tissue.
Pharmacological dissection of ANF secretion indicates an important
contribution of ICa,T to Ca2+
signaling during the neonatal period.
cardiac myocytes; atrial natriuretic factor; electrophysiology
This article has been cited by other articles:
|
|
 |
|
  M. E. Mangoni and J. Nargeot Genesis and Regulation of the Heart Automaticity Physiol Rev, July 1, 2008; 88(3): 919 - 982. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Varela, T. Hermosilla, and G. W. Zamponi Making the T-Type Even Tinier: Corticotropin-Releasing Factor-Mediated Inhibition of Low-Voltage-Activated Calcium Channel Activity Mol. Pharmacol., June 1, 2008; 73(6): 1589 - 1591. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Wang and E. A. Sobie Mathematical model of the neonatal mouse ventricular action potential Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2565 - H2575. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Traboulsie, J. Chemin, M. Chevalier, J.-F. Quignard, J. Nargeot, and P. Lory Subunit-specific modulation of T-type calcium channels by zinc J. Physiol., January 1, 2007; 578(1): 159 - 171. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Giancippoli, M. Novara, A. de Luca, P. Baldelli, A. Marcantoni, E. Carbone, and V. Carabelli Low-Threshold Exocytosis Induced by cAMP-Recruited CaV3.2 ({alpha}1H) Channels in Rat Chromaffin Cells Biophys. J., March 1, 2006; 90(5): 1830 - 1841. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Laleve, M. C. Rebsamen, S. Barrere-Lemaire, E. Perrier, J. Nargeot, J.-P. Benitah, and M. F. Rossier Aldosterone increases T-type calcium channel expression and in vitro beating frequency in neonatal rat cardiomyocytes Cardiovasc Res, August 1, 2005; 67(2): 216 - 224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Larsen, C.-C. Chen, and P. M. Best Disruption of growth hormone secretion alters Ca2+ current density and expression of Ca2+ channel and insulin-like growth factor genes in rat atria Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H829 - H838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Niwa, K. Yasui, T. Opthof, H. Takemura, A. Shimizu, M. Horiba, J.-K. Lee, H. Honjo, K. Kamiya, and I. Kodama Cav3.2 subunit underlies the functional T-type Ca2+ channel in murine hearts during the embryonic period Am J Physiol Heart Circ Physiol, June 1, 2004; 286(6): H2257 - H2263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Escobar, R. Ribeiro-Costa, C. Villalba-Galea, M. E. Zoghbi, C. G. Perez, and R. Mejia-Alvarez Developmental changes of intracellular Ca2+ transients in beating rat hearts Am J Physiol Heart Circ Physiol, March 1, 2004; 286(3): H971 - H978. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. M. Zhang, L. Shang, C. Hartzell, M. Narlow, L. Cribbs, and S. C. Dudley Jr. Characterization and regulation of T-type Ca2+ channels in embryonic stem cell-derived cardiomyocytes Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2770 - H2779. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-H. Liu, S. Konig, M. Michel, S. Arnaudeau, J. Fischer-Lougheed, C. R. Bader, and L. Bernheim Acceleration of human myoblast fusion by depolarization: graded Ca2+ signals involved Development, August 1, 2003; 130(15): 3437 - 3446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Perez-Reyes Molecular Physiology of Low-Voltage-Activated T-type Calcium Channels Physiol Rev, January 1, 2003; 83(1): 117 - 161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Protas, D. DiFrancesco, and R. B. Robinson L-type but not T-type calcium current changes during postnatal development in rabbit sinoatrial node Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1252 - H1259. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. L. Cribbs, B. L. Martin, E. A. Schroder, B. B. Keller, B. P. Delisle, and J. Satin Identification of the T-Type Calcium Channel (CaV3.1d) in Developing Mouse Heart Circ. Res., March 2, 2001; 88(4): 403 - 407. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
