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Am J Physiol Heart Circ Physiol 279: H2766-H2775, 2000;
0363-6135/00 $5.00
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Vol. 279, Issue 6, H2766-H2775, December 2000

Effect of estrogen on global myocardial ischemia-reperfusion injury in female rats

Peiyong Zhai1, Thomas E. Eurell1, Robert Cotthaus1, Elizabeth H. Jeffery1,2, Janice M. Bahr3, and David R. Gross1

1 Department of Veterinary Biosciences, 2 Department of Food Science and Human Nutrition, and 3 Department of Animal Sciences, University of Illinois, Urbana-Champaign, Illinois 61802

We investigated the effects of estrogen on global myocardial ischemia-reperfusion injury in rats that were ovariectomized (Ovx), sham-operated, or ovariectomized and then given 17beta -estradiol (E2beta ) supplementation (Ovx+E2beta ). Hearts were excised, cannulated, perfused with and then immersed in chilled (4°C) cardioplegia solution for 30 min, and then retrogradely perfused with warm (37°C), oxygenated Krebs-Henseleit bicarbonate buffer for 120 min. The coronary flow rate, first derivative of left ventricular pressure, and nitrite production were all significantly lower in Ovx than in sham-operated or Ovx+E2beta hearts. However, coronary flow rates or nitrate production were not consistently different throughout the entire reperfusion period. Ca2+ accumulated more in Ovx rat hearts than in sham-operated or Ovx+E2beta hearts, and mitochondrial respiratory function was lower in Ovx hearts than in hearts from the other two groups. Marked interstitial edema and contraction bands were seen in hematoxylin-eosin-stained sections of Ovx rat hearts but not in hearts from either of the other groups. Hematoxylin-basic fuchsin-picric acid-stained sections revealed fewer viable myocytes in hearts from the Ovx group than from the sham or Ovx+E2beta group. Transmission electron microscopy demonstrated more severely damaged mitochondria and ultrastructural damage to myocytes in Ovx rat hearts. Our results indicate that estrogen plays a cardioprotective role in global myocardial ischemia-reperfusion injury in female rats.

calcium; nitric oxide; mitochondrial function; myocardial ultrastructure


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