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Am J Physiol Heart Circ Physiol 279: H2994-H3002, 2000;
0363-6135/00 $5.00
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Vol. 279, Issue 6, H2994-H3002, December 2000

Effects of exercise training on cardiac function, gene expression, and apoptosis in rats

Hongkui Jin1, Renhui Yang1, Wei Li1, Hsienwie Lu1, Anne M. Ryan2, Annie K. Ogasawara1, John Van Peborgh1, and Nicholas F. Paoni1

1 Department of Cardiovascular Research and 2 Department of Pathology, Genentech Incorporated, South San Francisco, California 94080

This study determined the effects of exercise training on cardiac function, gene expression, and apoptosis. Rats exposed to a regimen of treadmill exercise for 13 wk had a significant increase in cardiac index and stroke volume index and a concomitant decrease in systemic vascular resistance compared with both age-matched and body weight-matched sedentary controls in the conscious state at rest. In exercise-trained animals, there was no change in the expression of several marker genes known to be associated with pathological cardiac adaptation, including atrial natriuretic factor, beta -myosin heavy chain, alpha -skeletal and smooth muscle actins, and collagens I and III. Exercise training, however, produced a significant induction of alpha -myosin heavy chain, which was not observed in rats with myocardial infarction. No histological features of cardiac apoptosis were observed in the treadmill-trained rats. In contrast, apoptotic myocytes were detected in animals with myocardial infarction. In summary, exercise training improves cardiac function without evidence of cardiac apoptosis and produces a pattern of cardiac gene expression distinct from pathological cardiac adaptation.

treadmill; hemodynamics; physiological loads; pathological loads; myocardial infarction


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