AJP - Heart Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 280: H420-H425, 2001;
0363-6135/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (8)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vandeputte, C.
Right arrow Articles by Capdeville-Atkinson, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vandeputte, C.
Right arrow Articles by Capdeville-Atkinson, C.
Vol. 280, Issue 1, H420-H425, January 2001

Melatonin potentiates NE-induced vasoconstriction without augmenting cytosolic calcium concentration

C. Vandeputte1, P. Giummelly1, J. Atkinson1, P. Delagrange2, E. Scalbert2, and C. Capdeville-Atkinson1

1 Laboratoire de Pharmacologie Cardiovasculaire, EA 3116, Faculté de Pharmacie, UHP-Nancy 1, 54001 Nancy Cedex; 2 Institut de Recherches Internationales Servier, 92415 Courbevoie Cedex, France

Because little is known of the intracellular mechanisms involved in the vasoconstrictor effect of melatonin (Mel), we examined the in vitro effects of Mel by using perfused cylindrical segments of the rat tail artery loaded with the intracellular Ca2+ concentration ([Ca2+]i)-sensitive fluorescent dye, fura 2. Mel (10-14 to 10-4 M) had no effect on baseline perfusion pressure or [Ca2+]i but increased, at submicromolar concentrations, the vasoconstrictor effect of norepinephrine (NE) (P = 0.0029). Mel did not modify NE-induced [Ca2+]i mobilization, and thus the [Ca2+]i sensitivity of NE-induced contraction increased in the presence of Mel. Mel consistently increased KCl-induced vasoconstriction and [Ca2+]i sensitivity of contraction, but differences were not statistically significant. In conclusion, Mel increases the [Ca2+]i sensitivity of vasoconstriction evoked by NE suggesting that Mel may amplify endogenous vasoconstrictor responses to sympathetic outflow.

tail artery; intracellular calcium; norepinephrine


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. Aoki, D. P. Stephens, K. Zhao, W. A. Kosiba, and J. M. Johnson
Modification of cutaneous vasodilator response to heat stress by daytime exogenous melatonin administration
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2006; 291(3): R619 - R624.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
C. A Ray
Melatonin attenuates the sympathetic nerve responses to orthostatic stress in humans
J. Physiol., September 15, 2003; 551(3): 1043 - 1048.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online