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Am J Physiol Heart Circ Physiol 280: H546-H553, 2001;
0363-6135/01 $5.00
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Vol. 280, Issue 2, H546-H553, February 2001

Elevated interstitial adenosine concentrations do not activate the muscle reflex

David A. MacLean1,2, Lisa M. Vickery1, and Lawrence I. Sinoway1,3

1 Division of Cardiology, Department of Medicine, and 2 Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, The Milton S. Hershey Medical Center, Hershey 17033; and 3 Lebanon Veterans Affairs Medical Center, Lebanon, Pennsylvania 17042

The purpose of the present study was to examine the effects of adenosine perfusion of the isolated triceps surae muscle group in the decerebrate cat on interstitial adenosine concentrations as well as heart rate and blood pressure responses. In six male cats (6.0 ± 0.21 kg), the triceps surae muscle group of both legs was perfused with an artificial blood solution containing no additives (control) and then with blood containing 20 mM or 100 µM adenosine for 10 min. An intact muscle reflex was confirmed by bolus injections of 50 mM phosphate and/or saturated KCl administered into the triceps surae muscle via the cannulated popliteal artery before and after adenosine blood perfusion. Microdialysis of the triceps surae muscle group during muscle perfusion revealed that interstitial adenosine was elevated (P < 0.05) from 0.9 ± 0.3 µM during control blood perfusion to 2,421 ± 547 µM during 20 mM adenosine perfusion. In addition, interstitial adenosine levels were increased (P < 0.05) from 1.1 ± 0.3 µM during control blood perfusion to 4.1 ± 1.2 µM during perfusion with 100 µM adenosine. Despite the large increases in interstitial adenosine levels, perfusion of the triceps surae muscle group with the two blood adenosine solutions resulted in no significant increases in heart rate or blood pressure. These data strongly suggest that elevated interstitial adenosine concentrations do not play a role in activating the muscle reflex and confirm our previous in vivo human findings (J Appl Physiol 83: 1045-1053, 1997).

microdialysis; perfusion; afferent; pressor


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