AJP - Heart AJP citation statistics
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 280: H554-H561, 2001;
0363-6135/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (36)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Garcia, M. J.
Right arrow Articles by Thomas, J. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Garcia, M. J.
Right arrow Articles by Thomas, J. D.
Vol. 280, Issue 2, H554-H561, February 2001

Estimation of left ventricular operating stiffness from Doppler early filling deceleration time in humans

Mario J. Garcia1, Michael S. Firstenberg1, Neil L. Greenberg1, Nicholas Smedira2, Leonardo Rodriguez1, David Prior1, and James D. Thomas1

1 Cardiovascular Imaging Center, Departments of Cardiology and 2 Cardiothoracic Sugery, Cleveland Clinic Foundation, Cleveland, Ohio 44195

Shortened early transmitral deceleration times (EDT) have been qualitatively associated with increased filling pressure and reduced survival in patients with cardiac disease and increased left ventricular operating stiffness (KLV). An equation relating KLV quantitatively to EDT has previously been described in a canine model but not in humans. During several varying hemodynamic conditions, we studied 18 patients undergoing open-heart surgery. Transesophageal echocardiographic two-dimensional volumes and Doppler flows were combined with high-fidelity left atrial (LA) and left ventricular (LV) pressures to determine KLV. From digitized Doppler recordings, EDT was measured and compared against changes in LV and LA diastolic volumes and pressures. EDT (180 ± 39 ms) was inversely associated with LV end-diastolic pressures (r = -0.56, P = 0.004) and net atrioventricular stiffness (r = -0.55, P = 0.006) but had its strongest association with KLV (r = -0.81, P < 0.001). KLV was predicted assuming a nonrestrictive orifice (Knonrest) from EDT as Knonrest = (0.07/EDT)2 with KLV = 1.01 Knonrest - 0.02; r = 0.86, P < 0.001, Delta K (Knonrest - KLV) = 0.02 ± 0.06 mmHg/ml. In adults with cardiac disease, EDT provides an accurate estimate of LV operating stiffness and supports its application as a practical noninvasive index in the evaluation of diastolic function.

diastole; echocardiography; myocardial stiffness


This article has been cited by other articles:


Home page
 J Am Coll Cardiol ImgHome page
A. T. Burns, A. La Gerche, D. L. Prior, and A. I. MacIsaac
Left Ventricular Untwisting Is an Important Determinant of Early Diastolic Function
J. Am. Coll. Cardiol. Img., June 1, 2009; 2(6): 709 - 716.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll Cardiol ImgHome page
Y. Notomi and J. D. Thomas
Presto Untwisting and Legato Filling
J. Am. Coll. Cardiol. Img., June 1, 2009; 2(6): 717 - 719.
[Full Text] [PDF]

Home page
 Eur J EchocardiogrHome page
S. F. Nagueh, C. P. Appleton, T. C. Gillebert, P. N. Marino, J. K. Oh, O. A. Smiseth, A. D. Waggoner, F. A. Flachskampf, P. A. Pellikka, and A. Evangelisa
Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography
Eur J Echocardiogr, March 1, 2009; 10(2): 165 - 193.
[Full Text] [PDF]

Home page
 HypertensionHome page
B. Lopez, R. Querejeta, A. Gonzalez, J. Beaumont, M. Larman, and J. Diez
Impact of Treatment on Myocardial Lysyl Oxidase Expression and Collagen Cross-Linking in Patients With Heart Failure
Hypertension, February 1, 2009; 53(2): 236 - 242.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
D. Akkan, J. Kjaergaard, J. E. Moller, C. Hassager, C. Torp-Pedersen, L. Kober, and EchoCardiography and Heart Outcome Study (ECHOS) i
Prognostic importance of a short deceleration time in symptomatic congestive heart failure
Eur J Heart Fail, July 1, 2008; 10(7): 689 - 695.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
O. L. Nelson, C. T. Robbins, Y. Wu, and H. Granzier
Titin isoform switching is a major cardiac adaptive response in hibernating grizzly bears
Am J Physiol Heart Circ Physiol, July 1, 2008; 295(1): H366 - H371.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
Meta-Analysis Research Group in Echocardiography (
Independent Prognostic Importance of a Restrictive Left Ventricular Filling Pattern After Myocardial Infarction: An Individual Patient Meta-Analysis: Meta-Analysis Research Group in Echocardiography Acute Myocardial Infarction
Circulation, May 20, 2008; 117(20): 2591 - 2598.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
L. Merello, E. Riesle, J. Alburquerque, H. Torres, E. Aranguiz-Santander, O. Pedemonte, and B. Westerberg
Risk Scores Do Not Predict High Mortality After Coronary Artery Bypass Surgery in the Presence of Diastolic Dysfunction
Ann. Thorac. Surg., April 1, 2008; 85(4): 1247 - 1255.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. Masutani, W. C. Little, H. Hasegawa, H.-J. Cheng, and C.-P. Cheng
Restrictive Left Ventricular Filling Pattern Does Not Result From Increased Left Atrial Pressure Alone
Circulation, March 25, 2008; 117(12): 1550 - 1554.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. Kasner, D. Westermann, P. Steendijk, R. Gaub, U. Wilkenshoff, K. Weitmann, W. Hoffmann, W. Poller, H.-P. Schultheiss, M. Pauschinger, et al.
Utility of Doppler Echocardiography and Tissue Doppler Imaging in the Estimation of Diastolic Function in Heart Failure With Normal Ejection Fraction: A Comparative Doppler-Conductance Catheterization Study
Circulation, August 7, 2007; 116(6): 637 - 647.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
L. Shmuylovich and S. J. Kovacs
E-wave deceleration time may not provide an accurate determination of LV chamber stiffness if LV relaxation/viscoelasticity is unknown
Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2712 - H2720.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
J. D. Thomas and Z. B. Popovic
Assessment of Left Ventricular Function by Cardiac Ultrasound
J. Am. Coll. Cardiol., November 21, 2006; 48(10): 2012 - 2025.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Slama, J. Ahn, M. Peltier, J. Maizel, D. Chemla, J. Varagic, D. Susic, C. Tribouilloy, and E. D. Frohlich
Validation of echocardiographic and Doppler indexes of left ventricular relaxation in adult hypertensive and normotensive rats
Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H1131 - H1136.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
P. Marino, G. Faggian, P. Bertolini, A. Mazzucco, and W. C. Little
Early mitral deceleration and left atrial stiffness
Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1172 - H1178.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. Ahn, J. Varagic, M. Slama, D. Susic, and E. D. Frohlich
Cardiac structural and functional responses to salt loading in SHR
Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H767 - H772.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. F. Nagueh, G. Shah, Y. Wu, G. Torre-Amione, N. M.P. King, S. Lahmers, C. C. Witt, K. Becker, S. Labeit, and H. L. Granzier
Altered Titin Expression, Myocardial Stiffness, and Left Ventricular Function in Patients With Dilated Cardiomyopathy
Circulation, July 13, 2004; 110(2): 155 - 162.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Slama, J. Ahn, J. Varagic, D. Susic, and E. D. Frohlich
Long-term left ventricular echocardiographic follow-up of SHR and WKY rats: effects of hypertension and age
Am J Physiol Heart Circ Physiol, January 1, 2004; 286(1): H181 - H185.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Rovner, R. Smith, N. L. Greenberg, E. M. Tuzcu, N. Smedira, H. M. Lever, J. D. Thomas, and M. J. Garcia
Improvement in diastolic intraventricular pressure gradients in patients with HOCM after ethanol septal reduction
Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2492 - H2499.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. Diez, R. Querejeta, B. Lopez, A. Gonzalez, M. Larman, and J. L. Martinez Ubago
Losartan-Dependent Regression of Myocardial Fibrosis Is Associated With Reduction of Left Ventricular Chamber Stiffness in Hypertensive Patients
Circulation, May 28, 2002; 105(21): 2512 - 2517.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. B. Lisauskas, J. Singh, A. W. Bowman, and S. J. Kovacs
Chamber properties from transmitral flow: prediction of average and passive left ventricular diastolic stiffness
J Appl Physiol, July 1, 2001; 91(1): 154 - 162.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
K. Wachtell, J. N. Bella, J. Rokkedal, V. Palmieri, V. Papademetriou, B. Dahlof, T. Aalto, E. Gerdts, and R. B. Devereux
Change in Diastolic Left Ventricular Filling After One Year of Antihypertensive Treatment: The Losartan Intervention For Endpoint Reduction in Hypertension (LIFE) Study
Circulation, March 5, 2002; 105(9): 1071 - 1076.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online