AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 280: H610-H620, 2001;
0363-6135/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (73)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bogaert, J.
Right arrow Articles by Rademakers, F. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bogaert, J.
Right arrow Articles by Rademakers, F. E.
Vol. 280, Issue 2, H610-H620, February 2001

Regional nonuniformity of normal adult human left ventricle

Jan Bogaert1 and Frank E. Rademakers2

Departments of 1 Radiology and 2 Cardiology, University Hospitals, Catholic University of Leuven, B-3000 Leuven, Belgium

Regional nonuniformity is a feature of both diseased and normal left ventricles (LV). With the use of magnetic resonance (MR) myocardial tagging, we performed three-dimensional strain analysis on 87 healthy adults in local cardiac and fiber coordinate systems (radial, circumferential, longitudinal, and fiber strains) to characterize normal nonuniformities and to test the validity of wall thickening as a parameter of regional function. Regional morphology included wall thickness and radii of curvature measurements. With respect to transmural nonuniformity, subendocardial strains exceeded subepicardial strains. Going from base to apex, wall thickness and circumferential radii of curvature decreased, whereas longitudinal radii of curvature increased. All of the strains increased from LV base to apex, resulting in a higher ejection fraction (EF) at the apex than at the base (70.9 ± 0.4 vs. 62.4 ± 0.4%; means ± SE, P < 0.0001). When we looked around the circumference of the ventricle, the anterior part of the LV was the flattest and thinnest and showed the largest wall thickening (46.6 ± 1.2%) but the lowest EF (64.7 ± 0.5%). The posterior LV wall was thicker, more curved, and showed a lower wall thickening (32.8 ± 1.0%) but a higher EF (71.3 ± 0.5%). The regional contribution of the LV wall to the ejection of blood is thus highly variable and is not fully characterized by wall thickening alone. Differences in regional LV architecture and probably local stress are possible explanations for this marked functional nonuniformity.

magnetic resonance; systolic function; morphology


This article has been cited by other articles:


Home page
 J. Thorac. Cardiovasc. Surg.Home page
G. Buckberg, A. Mahajan, S. Saleh, J. I.E. Hoffman, and C. Coghlan
Structure and function relationships of the helical ventricular myocardial band
J. Thorac. Cardiovasc. Surg., September 1, 2008; 136(3): 578 - 589.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EchocardiogrHome page
A. Baltabaeva, M. Marciniak, B. Bijnens, J. Moggridge, F. J. He, T. F. Antonios, G. A. MacGregor, and G. R. Sutherland
Regional left ventricular deformation and geometry analysis provides insights in myocardial remodelling in mild to moderate hypertension
Eur J Echocardiogr, July 1, 2008; 9(4): 501 - 508.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
V. Delgado, C. Ypenburg, R. J. van Bommel, L. F. Tops, S. A. Mollema, N. A. Marsan, G. B. Bleeker, M. J. Schalij, and J. J. Bax
Assessment of Left Ventricular Dyssynchrony by Speckle Tracking Strain Imaging: Comparison Between Longitudinal, Circumferential, and Radial Strain in Cardiac Resynchronization Therapy
J. Am. Coll. Cardiol., May 20, 2008; 51(20): 1944 - 1952.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EchocardiogrHome page
O. Tufekcioglu, D. Aras, A. Yildiz, S. Topaloglu, and O. Maden
Myocardial contraction properties along the long and short axes of the left ventricle in isolated left ventricular non-compaction: pulsed tissue Doppler echocardiography
Eur J Echocardiogr, May 1, 2008; 9(3): 344 - 350.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll Cardiol ImgHome page
P. P. Sengupta, V. K. Krishnamoorthy, W. P. Abhayaratna, J. Korinek, M. Belohlavek, T. M. Sundt III, K. Chandrasekaran, F. Mookadam, J. B. Seward, A. J. Tajik, et al.
Disparate Patterns of Left Ventricular Mechanics Differentiate Constrictive Pericarditis From Restrictive Cardiomyopathy
J. Am. Coll. Cardiol. Img., January 1, 2008; 1(1): 29 - 38.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
G. D. Buckberg
Congestive heart failure: Treat the disease, not the symptom Return to normalcy/Part II-The experimental approach.
J. Thorac. Cardiovasc. Surg., October 1, 2007; 134(4): 844 - 849.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
H. Ashikaga, B. A. Coppola, B. Hopenfeld, E. S. Leifer, E. R. McVeigh, and J. H. Omens
Transmural Dispersion of Myofiber Mechanics: Implications for Electrical Heterogeneity In Vivo
J. Am. Coll. Cardiol., February 27, 2007; 49(8): 909 - 916.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
M. J.W. Gotte, T. Germans, I. K. Russel, J. J.M. Zwanenburg, J. T. Marcus, A. C. van Rossum, and D. J. van Veldhuisen
Myocardial Strain and Torsion Quantified by Cardiovascular Magnetic Resonance Tissue Tagging: Studies in Normal and Impaired Left Ventricular Function
J. Am. Coll. Cardiol., November 21, 2006; 48(10): 2002 - 2011.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
P. P. Sengupta, J. Korinek, M. Belohlavek, J. Narula, M. A. Vannan, A. Jahangir, and B. K. Khandheria
Left Ventricular Structure and Function: Basic Science for Cardiac Imaging
J. Am. Coll. Cardiol., November 21, 2006; 48(10): 1988 - 2001.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Physiol.Home page
J. E. Stelzer, J. R. Patel, and R. L. Moss
Acceleration of Stretch Activation in Murine Myocardium due to Phosphorylation of Myosin Regulatory Light Chain
J. Gen. Physiol., August 28, 2006; 128(3): 261 - 272.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
O. J. Liakopoulos, H. Tomioka, G. D. Buckberg, Z. Tan, N. Hristov, and G. Trummer
Sequential deformation and physiological considerations in unipolar right or left ventricular pacing
Eur. J. Cardiothorac. Surg., April 1, 2006; 29(Suppl_1): S188 - S197.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
G. D. Buckberg and the RESTORE Group
Form versus disease: optimizing geometry during ventricular restoration
Eur. J. Cardiothorac. Surg., April 1, 2006; 29(Suppl_1): S238 - S244.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
K. A. Connelly, D. L. Prior, D. J. Kelly, M. P. Feneley, H. Krum, and R. E. Gilbert
Load-sensitive measures may overestimate global systolic function in the presence of left ventricular hypertrophy: a comparison with load-insensitive measures
Am J Physiol Heart Circ Physiol, April 1, 2006; 290(4): H1699 - H1705.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
K. Serri, P. Reant, M. Lafitte, M. Berhouet, V. Le Bouffos, R. Roudaut, and S. Lafitte
Global and Regional Myocardial Function Quantification by Two-Dimensional Strain: Application in Hypertrophic Cardiomyopathy
J. Am. Coll. Cardiol., March 21, 2006; 47(6): 1175 - 1181.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Y. L. Protsenko, S. M. Routkevitch, V. Y. Gur'ev, L. B. Katsnelson, O. Solovyova, O. N. Lookin, A. A. Balakin, P. Kohl, and V. S. Markhasin
Hybrid duplex: a novel method to study the contractile function of heterogeneous myocardium
Am J Physiol Heart Circ Physiol, December 1, 2005; 289(6): H2733 - H2746.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. Chen, W. Liu, H. Zhang, L. Lacy, X. Yang, S.-K. Song, S. A. Wickline, and X. Yu
Regional ventricular wall thickening reflects changes in cardiac fiber and sheet structure during contraction: quantification with diffusion tensor MRI
Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H1898 - H1907.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. P. Sengupta, B. K. Khandheria, J. Korinek, J. Wang, and M. Belohlavek
Biphasic tissue Doppler waveforms during isovolumic phases are associated with asynchronous deformation of subendocardial and subepicardial layers
J Appl Physiol, September 1, 2005; 99(3): 1104 - 1111.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
B. D. Rosen, T. Edvardsen, S. Lai, E. Castillo, L. Pan, M. Jerosch-Herold, S. Sinha, R. Kronmal, D. Arnett, J. R. Crouse III, et al.
Left Ventricular Concentric Remodeling Is Associated With Decreased Global and Regional Systolic Function: The Multi-Ethnic Study of Atherosclerosis
Circulation, August 16, 2005; 112(7): 984 - 991.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
F. Weidemann, F. Breunig, M. Beer, J. Sandstede, S. Stork, W. Voelker, G. Ertl, A. Knoll, C. Wanner, and J. M. Strotmann
The variation of morphological and functional cardiac manifestation in Fabry disease: potential implications for the time course of the disease
Eur. Heart J., June 2, 2005; 26(12): 1221 - 1227.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Cheng, F. Langer, F. Rodriguez, J. C. Criscione, G. T. Daughters, D. C. Miller, and N. B. Ingels Jr.
Transmural cardiac strains in the lateral wall of the ovine left ventricle
Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1546 - H1556.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
G. D. Buckberg
Editorial comment: New technology and old responsibilities
Eur. J. Cardiothorac. Surg., March 1, 2005; 27(3): 472 - 474.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. J. M. Zwanenburg, M. J. W. Gotte, J. P. A. Kuijer, M. B. M. Hofman, P. Knaapen, R. M. Heethaar, A. C. van Rossum, and J. T. Marcus
Regional timing of myocardial shortening is related to prestretch from atrial contraction: assessment by high temporal resolution MRI tagging in humans
Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H787 - H794.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. N. Mazzadi, M. F. Janier, B. Brossier, X. Andre-Fouet, D. Revel, and P. Croisille
Tagged MRI and PET in severe CAD: discrepancy between preoperative inotropic reserve and intramyocardial functional outcome after revascularization
Am J Physiol Heart Circ Physiol, November 1, 2004; 287(5): H2226 - H2233.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
B. D. Rosen, B. L. Gerber, T. Edvardsen, E. Castillo, L. C. Amado, K. Nasir, D. L. Kraitchman, N. F. Osman, D. A. Bluemke, and J. A. C. Lima
Late systolic onset of regional LV relaxation demonstrated in three-dimensional space by MRI tissue tagging
Am J Physiol Heart Circ Physiol, October 1, 2004; 287(4): H1740 - H1746.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. N. Mazzadi, M. F. Janier, B. Brossier, X. Andre-Fouet, E. McFadden, D. Revel, and P. Croisille
Dobutamine-tagged MRI for inotropic reserve assessment in severe CAD: relationship with PET findings
Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H1946 - H1953.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Poelzing, F. G. Akar, E. Baron, and D. S. Rosenbaum
Heterogeneous connexin43 expression produces electrophysiological heterogeneities across ventricular wall
Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H2001 - H2009.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. Ashikaga, J. C. Criscione, J. H. Omens, J. W. Covell, and N. B. Ingels Jr.
Transmural left ventricular mechanics underlying torsional recoil during relaxation
Am J Physiol Heart Circ Physiol, February 1, 2004; 286(2): H640 - H647.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. P. Katra, E. Pruvot, and K. R. Laurita
Intracellular calcium handling heterogeneities in intact guinea pig hearts
Am J Physiol Heart Circ Physiol, February 1, 2004; 286(2): H648 - H656.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. G. Fonseca, H. C. Oxenham, B. R. Cowan, C. J. Occleshaw, and A. A. Young
Aging alters patterns of regional nonuniformity in LV strain relaxation: a 3-D MR tissue tagging study
Am J Physiol Heart Circ Physiol, July 11, 2003; 285(2): H621 - H630.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. D'hooge, L. Herbots, G. R. Sutherland, O. A. Smiseth, T. Edvardsen, B. L. Gerber, J. Garot, D. A. Bluemke, and J. A.C. Lima
Quantitative Assessment of Intrinsic Regional Myocardial Deformation by Doppler Strain Rate Echocardiography in Humans * Response
Circulation, February 25, 2003; 107 (7): e49 - e49.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. C. Marshall, P. Powers-Risius, B. W. Reutter, A. M. Schustz, C. Kuo, M. K. Huesman, and R. H. Huesman
Flow heterogeneity following global no-flow ischemia in isolated rabbit heart
Am J Physiol Heart Circ Physiol, February 1, 2003; 284(2): H654 - H667.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
C. Christoffersen, J. P. Goetze, E. D. Bartels, M. O. Larsen, U. Ribel, J. F. Rehfeld, B. Rolin, and L. B. Nielsen
Chamber-Dependent Expression of Brain Natriuretic Peptide and Its mRNA in Normal and Diabetic Pig Heart
Hypertension, July 1, 2002; 40(1): 54 - 60.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
M. K. Pasque
Mathematic modeling and cardiac surgery
J. Thorac. Cardiovasc. Surg., April 1, 2002; 123(4): 617 - 620.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. J. Sinusas, X. Papademetris, R. T. Constable, D. P. Dione, M. D. Slade, P. Shi, and J. S. Duncan
Quantification of 3-D regional myocardial deformation: shape-based analysis of magnetic resonance images
Am J Physiol Heart Circ Physiol, August 1, 2001; 281(2): H698 - H714.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
B. D. Rosen, T. Edvardsen, S. Lai, E. Castillo, L. Pan, M. Jerosch-Herold, S. Sinha, R. Kronmal, D. Arnett, J. R. Crouse III, et al.
Left Ventricular Concentric Remodeling Is Associated With Decreased Global and Regional Systolic Function: The Multi-Ethnic Study of Atherosclerosis
Circulation, August 16, 2005; 112(7): 984 - 991.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online