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Am J Physiol Heart Circ Physiol 280: H628-H633, 2001;
0363-6135/01 $5.00
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Vol. 280, Issue 2, H628-H633, February 2001

Effects of acupuncture on radial artery hemodynamics: controlled trials in sensitized and naive subjects

Pierre Boutouyrie1, Robert Corvisier3, Michel Azizi2, Dominique Lemoine3, Brigitte Laloux1, Marie-Charlotte Hallouin2, and Stéphane Laurent1

1 Department of Pharmacology and Unité, Institut National de la Santé et de la Recherche Médicale U 337, and 2 Clinical Investigations Center, Hôpital Européen Georges Pompidou, Paris; 3 7 Mail Françis de Miomandre, Les Fontaines, 37200 Tours; 4 Commissariat à l'Energie Atomique, Le Ripault, 37260 Monts, France

Palpation of the radial pulses is an important technique in traditional Chinese medicine. Two double-blind randomized trials of the effects of real and sham acupuncture on radial artery hemodynamics were conducted in 19 patients regularly exposed to acupuncture (sensitized subjects) and in 8 healthy subjects devoid of previous exposure (naive subjects), respectively. Radial artery diameter and pulse waveform were measured with a high-resolution echotracking system and aplanation tonometry, respectively, before and during a 20-min acupuncture period. In sensitized patients, arterial diameter significantly increased during real acupuncture, compared with the sham group (+7.5 ± 2.8 vs. -2.9 ± 2.7%, respectively; P < 0.01). By contrast, in naive subjects, arterial diameter did not change during real or sham acupuncture. In both populations, no significant difference was observed between real and sham acupuncture, concerning the time course of blood pressure, radial artery distensibility, and pressure waveform. Our results demonstrate that real acupuncture is associated with an objective vasodilatation of the radial artery in patients regularly exposed to acupuncture, but not in naive subjects.

randomized trial


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