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Am J Physiol Heart Circ Physiol 280: H1208-H1214, 2001;
0363-6135/01 $5.00
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Vol. 280, Issue 3, H1208-H1214, March 2001

Cardioprotection is strain dependent in rat in response to whole body hyperthermia

Hemal H. Patel, Anna Hsu, and Garrett J. Gross

Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226

Previous results showed a genetic component to cardioprotection. Therefore, we investigated the heat shock response in Wistar and Sprague-Dawley (SD) rats at 24 and 48 h. Rats were subjected to whole body hyperthermia achieving colonic temperatures of 40 or 42°C for 20 min. After recovery hearts were excised for protein measurements or were subjected to 30 min of ischemia and then 2 h of reperfusion. Heat shock protein (HSP) expression was determined by Western blotting and infarct size was determined by triphenyltetrazolium staining. All groups of SD and Wistar rats demonstrated HSP72 and HSP90 induction at both time points in response to a heat stress of 42°C. At 24 h there was only a significant reduction in infarct size seen in control vs. small SD (60.0 ± 4.8 vs. 26.5 ± 2.3) rats. However, at 48 h control versus small SD (60.0 ± 4.8 vs. 17.6 ± 3.8) and Wistar (59.4 ± 4.3 vs. 29.8 ± 6.0) and control versus large SD (53.7 ± 2.6 vs. 19.8 ± 4.7) and Wistar (57.3 ± 1.6 vs. 34.5 ± 2.8) rats demonstrated a significant reduction in infarct size with a greater reduction observed in SD rats. We conclude that heat shock-induced cardioprotection in rats is dependent on strain, temperature, time after stress, and size.

heat shock proteins; genetic; infarct size


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