| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
O2 max and cardiac hypertrophy
1 Department of Physiology and Biomedical Engineering and 2 Department of Sport Sciences, Norwegian University of Science and Technology, N-7489 Trondheim, Norway
Physiological studies of long-term cardiovascular adaptation to
exercise require training regimens that give robust conditioning effects and adequate testing procedures to quantify the outcome. We
developed a valid and reproducible protocol for measuring maximal oxygen uptake (
O2 max), which was
reached at a 25° inclination with a respiratory exchange ratio > 1.05 and blood lactate > 6 mmol/l. The effect of
intensity-controlled aerobic endurance training was studied in adult
female and male rats that ran 2 h/day, 5 days/wk, in intervals of 8 min
at 85-90% of O2 max and 2 min at
50-60% of O2 max, with adjustment
of exercise level according to O2 max
every week. After 7 wk, the increase in
O2 max plateaued at 60-70% above
sedentary controls. Ventricular weights and myocyte length were up
25-30% and 6-12%, respectively. Work economy, oxygen pulse,
and heart rate were sufficiently changed to indicate substantial
cardiovascular adaptation. The model mimics important human responses
to training and could be used in future studies on cellular, molecular,
and integrative mechanisms of improved cardiovascular function.
oxygen pulse; heart rate; respiratory exchange ratio; maximal oxygen uptake
This article has been cited by other articles:
|
|
 |
|
  P. A. Figueiredo, S. K. Powers, R. M. Ferreira, F. Amado, H. J. Appell, and J. A. Duarte Impact of Lifelong Sedentary Behavior on Mitochondrial Function of Mice Skeletal Muscle J Gerontol A Biol Sci Med Sci, May 22, 2009; (2009) glp066v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Bye, M. A. Hoydal, D. Catalucci, M. Langaas, O. J. Kemi, V. Beisvag, L. G. Koch, S. L. Britton, O. Ellingsen, and U. Wisloff Gene expression profiling of skeletal muscle in exercise-trained and sedentary rats with inborn high and low VO2max Physiol Genomics, November 12, 2008; 35(3): 213 - 221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bye, M. Langaas, M. A. Hoydal, O. J. Kemi, G. Heinrich, L. G. Koch, S. L. Britton, S. M. Najjar, O. Ellingsen, and U. Wisloff Aerobic capacity-dependent differences in cardiac gene expression Physiol Genomics, October 8, 2008; 33(1): 100 - 109. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Boissiere, V. Eder, M.-C. Machet, D. Courteix, and P. Bonnet Moderate exercise training does not worsen left ventricle remodeling and function in untreated severe hypertensive rats J Appl Physiol, February 1, 2008; 104(2): 321 - 327. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. J. Kemi, M. A. Hoydal, P. M. Haram, A. Garnier, D. Fortin, R. Ventura-Clapier, and O. Ellingsen Exercise training restores aerobic capacity and energy transfer systems in heart failure treated with losartan Cardiovasc Res, October 1, 2007; 76(1): 91 - 99. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S J Warden Animal models for the study of tendinopathy Br. J. Sports Med., April 1, 2007; 41(4): 232 - 240. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Adams, A. Linke, U. Wisloff, C. Doring, S. Erbs, N. Krankel, C. C. Witt, S. Labeit, U. Muller-Werdan, G. Schuler, et al. Myocardial expression of Murf-1 and MAFbx after induction of chronic heart failure: Effect on myocardial contractility Cardiovasc Res, January 1, 2007; 73(1): 120 - 129. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ishikawa, W. Mizunoya, T. Shibakusa, K. Inoue, and T. Fushiki Transforming growth factor-beta in the brain regulates fat metabolism during endurance exercise Am J Physiol Endocrinol Metab, December 1, 2006; 291(6): E1151 - E1159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. S. Evangelista and J. E. Krieger Small gene effect and exercise training-induced cardiac hypertrophy in mice: an Ace gene dosage study Physiol Genomics, November 21, 2006; 27(3): 231 - 236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Iemitsu, S. Maeda, S. Jesmin, T. Otsuki, Y. Kasuya, and T. Miyauchi Activation pattern of MAPK signaling in the hearts of trained and untrained rats following a single bout of exercise J Appl Physiol, July 1, 2006; 101(1): 151 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. J. Kemi, P. M. Haram, J. P. Loennechen, J.-B. Osnes, T. Skomedal, U. Wisloff, and O. Ellingsen Moderate vs. high exercise intensity: Differential effects on aerobic fitness, cardiomyocyte contractility, and endothelial function Cardiovasc Res, July 1, 2005; 67(1): 161 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. L. Billat, E. Mouisel, N. Roblot, and J. Melki Inter- and intrastrain variation in mouse critical running speed J Appl Physiol, April 1, 2005; 98(4): 1258 - 1263. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Massett and B. C. Berk Strain-dependent differences in responses to exercise training in inbred and hybrid mice Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2005; 288(4): R1006 - R1013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. G. Koch, C. L. Green, A. D. Lee, J. E. Hornyak, G. T. Cicila, and S. L. Britton Test of the principle of initial value in rat genetic models of exercise capacity Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2005; 288(2): R466 - R472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Reboul, S. Tanguy, J. M. Juan, M. Dauzat, and P. Obert Cardiac remodeling and functional adaptations consecutive to altitude training in rats: implications for sea level aerobic performance J Appl Physiol, January 1, 2005; 98(1): 83 - 92. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. M. Olfert, J. Balouch, and O. Mathieu-Costello Oxygen Consumption During Maximal Exercise in Fischer 344 x Brown Norway F1 Hybrid Rats J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2004; 59(8): B801 - B808. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. O. Boluyt, A. M. Loyd, M. H. Roth, M. J. Randall, and E. Y. M. Song Activation of JNK in rat heart by exercise: effect of training Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2639 - H2647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Troxell, S. L. Britton, and L. G. Koch Genetic Models in Applied Physiology: Selected Contribution: Variation and heritability for the adaptational response to exercise in genetically heterogeneous rats J Appl Physiol, April 1, 2003; 94(4): 1674 - 1681. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Wisloff, R. S Richardson, and A. O Brubakk NOS inhibition increases bubble formation and reduces survival in sedentary but not exercised rats J. Physiol., January 15, 2003; 546(2): 577 - 582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. J. Kemi, J. P. Loennechen, U. Wisloff, and O. Ellingsen Intensity-controlled treadmill running in mice: cardiac and skeletal muscle hypertrophy J Appl Physiol, October 1, 2002; 93(4): 1301 - 1309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Wisloff, J. P. Loennechen, S. Currie, G. L. Smith, and O. Ellingsen Aerobic exercise reduces cardiomyocyte hypertrophy and increases contractility, Ca2+ sensitivity and SERCA-2 in rat after myocardial infarction Cardiovasc Res, April 1, 2002; 54(1): 162 - 174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Wisloff and A. O Brubakk Aerobic endurance training reduces bubble formation and increases survival in rats exposed to hyperbaric pressure J. Physiol., December 1, 2001; 537(2): 607 - 611. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
