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Am J Physiol Heart Circ Physiol 280: H1311-H1317, 2001;
0363-6135/01 $5.00
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Vol. 280, Issue 3, H1311-H1317, March 2001

Keratinocyte growth factor attenuates hydrostatic pulmonary edema in an isolated, perfused rat lung model

David A. Welsh1, Benoit P. H. Guery3, Bennett P. Deboisblanc1, Elizabeth P. Dobard1, Colette Creusy4, Donald Mercante2, Steve Nelson1, Warren R. Summer1, and Carol M. Mason1

Departments of 1 Medicine and 2 Biometry, Louisiana State University Medical Center, New Orleans, Louisiana 70112; and 3 Laboratoire de Recherche en Pathologie Infectieuse and Laboratoire de Biophysique and 4 Service d'Anatomie et de Cytologie Pathologique, Faculte de Medecine, Universite Catholique de Lille, Lille, France

Hydrostatic pulmonary edema is a common complication of congestive heart failure, resulting in substantial morbidity and mortality. Keratinocyte growth factor (KGF) is a mitogen for type II alveolar epithelial and microvascular cells. We utilized the isolated perfused rat lung model to produce hydrostatic pulmonary edema by varying the left atrial and pulmonary capillary pressure. Pretreatment with KGF attenuated hydrostatic edema formation. This was demonstrated by lower wet-to-dry lung weight ratios, histological evidence of less alveolar edema formation, and reduced alveolar accumulation of intravascularly administered FITC-labeled large-molecular-weight dextran in rats pretreated with KGF. Thus KGF attenuates injury in this ex vivo model of hydrostatic pulmonary edema via mechanisms that prevent increases in alveolar-capillary permeability.

alveolar epithelial permeability; pulmonary capillary pressure; fluorescein isothiocyanate-labeled dextran


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