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-mediated
cardioprotection: the signaling module hypothesis
1 Department of Physiology and Biophysics, 2 Department of Medicine/Division of Cardiology and Division of Nephrology, 3 Department of Biochemistry, 4 Core Proteomics Laboratory at University of Louisville and Department of Veterans Affairs, and the Jewish Hospital Heart and Lung Institute, Louisville, Kentucky 40202-1783
The
characterization of biological processes on the basis of alterations in
the cellular proteins, or "proteomic" analysis, is a powerful
approach that may be adopted to decipher the signaling mechanisms that
underlie various pathophysiological conditions, such as ischemic
heart disease. This review represents a prospectus for the
implementation of proteomic analyses to delineate the myocardial
intracellular signaling events that evoke cardioprotection against
ischemic injury. In concert with this, the manifestation of a
protective phenotype has recently been shown to involve dynamic modulation of protein kinase C-
(PKC) signaling complexes (Ping P, Zhang J, Pierce WM Jr, and Bolli R. Circ Res 88:
59-62, 2001). Accordingly, "the signaling module hypothesis"
is formulated as a plausible mechanism by which multipurpose
stress-activated proteins and signaling kinases may function
collectively to facilitate the genesis of cardioprotection.
heart; protein kinase C; preconditioning; protein kinases; signaling
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