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1 Department of Clinical Pharmacology and 2 Department of Ophthalmology, 3 Institute of Medical Physics, Vienna University, A-1090 Vienna, Austria
The aim of the present study was to
investigate the association between ultrasound Doppler measurements of
resistive index (RI) in the central retinal artery and retinal vascular
resistance (R) assessed with laser Doppler velocimetry,
vessel size measurement, and calculation of ocular perfusion pressure
(PP) in healthy subjects. An increase in vascular resistance was
induced by inhalation of 100% O2. During hyperoxia no
significant changes in PP were observed. Mean flow velocity in main
retinal veins was reduced by 
27.5 ± 2.0%. The average decrease
in diameter was 11.5 ± 1.0%. R, which was
calculated as the ratio of PP to flow rate, increased by 97.6 ± 7.7%. RI increased as well, but the effect was much smaller (6.6 ± 2.2%). In addition, a negative correlation was found between
baseline values of R and RI (r = 0.83). During hyperoxia R and RI were not associated. In conclusion, our
data indicate that RI as assessed with color Doppler imaging in the central retinal artery is not an adequate measure of R.
retinal blood flow; mean flow velocity; venous diameter; hyperoxia
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