AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 280: H1490-H1495, 2001;
0363-6135/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (30)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Leffler, C. W.
Right arrow Articles by Fedinec, A. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Leffler, C. W.
Right arrow Articles by Fedinec, A. L.
Vol. 280, Issue 4, H1490-H1495, April 2001

Contributions of prostacyclin and nitric oxide to carbon monoxide-induced cerebrovascular dilation in piglets

Charles W. Leffler1, Alberto Nasjletti2, Robert A. Johnson3, and Alexander L. Fedinec1

1 Laboratory for Research in Neonatal Physiology, Departments of Physiology and Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee 38163; 2 Department of Pharmacology, New York Medical College, Valhalla, New York 10595; and 3 Department of Physiology, Tulane University School of Medicine, New Orleans, Louisiana 70112

Carbon monoxide (CO) is an endogenous dilator in the newborn cerebral microcirculation. Other dilators include prostanoids and nitric oxide (NO), and interactions among the systems are likely. Experiments on anesthetized piglets with cranial windows address the hypothesis that CO-induced dilation of pial arterioles involves interaction with the prostanoid and NO systems. Topical application of CO or the heme oxygenase substrate heme-L-lysinate (HLL) produced dilation. Indomethacin, Nomega -nitro-L-arginine (L-NNA), and either iberiotoxin or tetraethylammonium chloride (TEA) were used to inhibit prostanoids, NO, and Ca2+-activated K+ (KCa) channels, respectively. Indomethacin, L-NNA, iberiotoxin, or TEA blocked cerebral vasodilation to CO and HLL. Vasodilations to both CO and HLL were returned to indomethacin-treated piglets by topical application of iloprost. Vasodilations to both CO and HLL were returned to L-NNA-treated piglets by sodium nitroprusside but not iloprost. In iberiotoxin- or TEA-treated piglets, dilations to CO and HLL could not be restored by either iloprost or sodium nitroprusside. The dilator actions of CO involve prostacyclin and NO as permissive enablers. The permissive actions of prostacyclin and NO may alter the KCa channel response to CO because neither iloprost nor sodium nitroprusside could restore dilation to CO when these channels were blocked.

heme oxygenase; permissive, potassium channels


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Kanu and C. W. Leffler
Carbon monoxide and Ca2+-activated K+ channels in cerebral arteriolar responses to glutamate and hypoxia in newborn pigs
Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H3193 - H3200.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Kanu, J. Whitfield, and C. W. Leffler
Carbon monoxide contributes to hypotension-induced cerebrovascular vasodilation in piglets
Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2409 - H2414.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
S. Chlopicki, R. Olszanecki, E. Marcinkiewicz, M. Lomnicka, and R. Motterlini
Carbon monoxide released by CORM-3 inhibits human platelets by a mechanism independent of soluble guanylate cyclase
Cardiovasc Res, July 15, 2006; 71(2): 393 - 401.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
S. W. Ryter, J. Alam, and A. M. K. Choi
Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications
Physiol Rev, April 1, 2006; 86(2): 583 - 650.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. W. Leffler, H. Parfenova, J. H. Jaggar, and R. Wang
Carbon monoxide and hydrogen sulfide: gaseous messengers in cerebrovascular circulation
J Appl Physiol, March 1, 2006; 100(3): 1065 - 1076.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Rebel, S. Cao, H. Kwansa, S. Dore, E. Bucci, and R. C. Koehler
Dependence of acetylcholine and ADP dilation of pial arterioles on heme oxygenase after transfusion of cell-free polymeric hemoglobin
Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1027 - H1037.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
L. Wu and R. Wang
Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications
Pharmacol. Rev., December 1, 2005; 57(4): 585 - 630.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. W. Leffler, L. Balabanova, A. L. Fedinec, and H. Parfenova
Nitric oxide increases carbon monoxide production by piglet cerebral microvessels
Am J Physiol Heart Circ Physiol, October 1, 2005; 289(4): H1442 - H1447.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. W. Leffler, A. L. Fedinec, H. Parfenova, and J. H. Jaggar
Permissive contributions of NO and prostacyclin in CO-induced cerebrovascular dilation in piglets
Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H432 - H438.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
E. Barkoudah, J. H. Jaggar, and C. W. Leffler
The permissive role of endothelial NO in CO-induced cerebrovascular dilation
Am J Physiol Heart Circ Physiol, October 1, 2004; 287(4): H1459 - H1465.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Q. Xi, D. Tcheranova, H. Parfenova, B. Horowitz, C. W. Leffler, and J. H. Jaggar
Carbon monoxide activates KCa channels in newborn arteriole smooth muscle cells by increasing apparent Ca2+ sensitivity of {alpha}-subunits
Am J Physiol Heart Circ Physiol, February 1, 2004; 286(2): H610 - H618.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
P. Koneru and C. W. Leffler
Role of cGMP in carbon monoxide-induced cerebral vasodilation in piglets
Am J Physiol Heart Circ Physiol, January 1, 2004; 286(1): H304 - H309.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
E. Fiumana, H. Parfenova, J. H. Jaggar, and C. W. Leffler
Carbon monoxide mediates vasodilator effects of glutamate in isolated pressurized cerebral arterioles of newborn pigs
Am J Physiol Heart Circ Physiol, April 1, 2003; 284 (4): H1073 - H1079.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. S. Naik, T. L. O'Donaughy, and B. R. Walker
Endogenous carbon monoxide is an endothelial-derived vasodilator factor in the mesenteric circulation
Am J Physiol Heart Circ Physiol, March 1, 2003; 284(3): H838 - H845.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. S. Robinson, A. L. Fedinec, and C. W. Leffler
Role of carbon monoxide in glutamate receptor-induced dilation of newborn pig pial arterioles
Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2371 - H2376.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
H. Parfenova, R. A. Neff III, J. S. Alonso, B. V. Shlopov, C. N. Jamal, S. A. Sarkisova, and C. W. Leffler
Cerebral vascular endothelial heme oxygenase: expression, localization, and activation by glutamate
Am J Physiol Cell Physiol, December 1, 2001; 281(6): C1954 - C1963.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. L. Xu, R. A. Santizo, H. M. Koenig, and D. A. Pelligrino
Chronic estrogen depletion alters adenosine diphosphate-induced pial arteriolar dilation in female rats
Am J Physiol Heart Circ Physiol, November 1, 2001; 281(5): H2105 - H2112.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. S. Robinson, A. L. Fedinec, and C. W. Leffler
Role of carbon monoxide in glutamate receptor-induced dilation of newborn pig pial arterioles
Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2371 - H2376.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online