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1 Department of Integrative Physiology and Cardiovascular Research Institute, University of North Texas Health Science Center, Fort Worth, Texas 76107; and 2 Copenhagen Muscle Research Center, Department of Anesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
This
investigation was designed to determine central command's role on
carotid baroreflex (CBR) resetting during exercise. Nine volunteer
subjects performed static and rhythmic handgrip exercise at 30 and 40%
maximal voluntary contraction (MVC), respectively, before and after
partial axillary neural blockade. Stimulus-response curves were
developed using the neck pressure-neck suction technique and a rapid
pulse train protocol (+40 to 
80 Torr). Regional anesthesia resulted
in a significant reduction in MVC. Heart rate (HR) and ratings of
perceived exertion (RPE) were used as indexes of central command and
were elevated during exercise at control force intensity after induced
muscle weakness. The CBR function curves were reset vertically with a
minimal lateral shift during control exercise and exhibited a further
parallel resetting during exercise with neural blockade. The operating
point was progressively reset to coincide with the centering point of
the CBR curve. These data suggest that central command was a primary
mechanism in the resetting of the CBR during exercise. However, it
appeared that central command modulated the carotid-cardiac reflex
proportionately more than the carotid-vasomotor reflex.
blood pressure; anesthesia; paralysis; cardiovascular control
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