AJP - Heart Journal of Neurophysiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 280: H1770-H1781, 2001;
0363-6135/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (19)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mor-Avi, V.
Right arrow Articles by Lang, R. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mor-Avi, V.
Right arrow Articles by Lang, R. M.
Vol. 280, Issue 4, H1770-H1781, April 2001

Detection of regional temporal abnormalities in left ventricular function during acute myocardial ischemia

Victor Mor-Avi, Keith A. Collins, Claudia E. Korcarz, Milind Shah, Kirk T. Spencer, and Roberto M. Lang

The Noninvasive Cardiac Imaging Laboratory, University of Chicago, Chicago, Illinois 60637

Echocardiographic diagnosis of myocardial ischemia is based on visualizing hypokinesis, which occurs late in the ischemic cascade. We hypothesized that temporal changes in endocardial motion may constitute sensitive early markers of ischemia. Two protocols were performed in 19 anesthetized pigs. Protocol 1 included 54 intracoronary balloon occlusions. Transthoracic images were acquired at baseline and every 15 s during 5 min of occlusion and reperfusion. In protocol 2, ischemia was induced in 12 animals by use of graded dobutamine infusion, after creating significant partial occlusions without a resting wall motion abnormality. Systolic and diastolic endocardial motion was color encoded using color kinesis and analyzed using custom software. All ischemic episodes caused detectable and reversible changes. The earliest sign of ischemia was tardokinesis in 31/54 occlusions, whereas hypokinesis appeared first in 23/54 cases. Dobutamine-induced ischemia caused tardokinesis first in 9/12 and hypokinesis in 3/12 animals. Reversible ischemic changes in regional left ventricular performance can be objectively detected using analysis of echocardiographic images and will likely improve the early noninvasive diagnosis of acute ischemia.

ultrasound imaging; ventricular function; endocardial motion; color kinesis


This article has been cited by other articles:


Home page
 Eur J EchocardiogrHome page
B. Cosyns, G. Van Camp, S. Droogmans, C. Weytjens, D. Schoors, and P. Lancellotti
Analysis of regional wall motion during contrast-enhanced dobutamine stress echocardiography: effect of contrast imaging settings
Eur J Echocardiogr, December 1, 2009; 10(8): 956 - 960.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
K. Ishii, T. Suyama, M. Imai, M. Maenaka, A. Yamanaka, Y. Makino, Y. Seino, K. Shimada, and J. Yoshikawa
Abnormal regional left ventricular systolic and diastolic function in patients with coronary artery disease undergoing percutaneous coronary intervention: clinical significance of post-ischemic diastolic stunning.
J. Am. Coll. Cardiol., October 20, 2009; 54(17): 1589 - 1597.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
K. Ishii, M. Imai, T. Suyama, M. Maenaka, T. Nagai, M. Kawanami, and Y. Seino
Exercise-Induced Post-Ischemic Left Ventricular Delayed Relaxation or Diastolic Stunning Is it a Reliable Marker in Detecting Coronary Artery Disease?
J. Am. Coll. Cardiol., February 24, 2009; 53(8): 698 - 705.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll Cardiol ImgHome page
F. Xie, S. Dodla, E. O'Leary, and T. R. Porter
Detection of subendocardial ischemia in the left anterior descending coronary artery territory with real-time myocardial contrast echocardiography during dobutamine stress echocardiography.
J. Am. Coll. Cardiol. Img., May 1, 2008; 1(3): 271 - 278.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. M. Tsutsui, A. Elhendy, J. R. Anderson, F. Xie, A. C. McGrain, and T. R. Porter
Prognostic Value of Dobutamine Stress Myocardial Contrast Perfusion Echocardiography
Circulation, September 6, 2005; 112(10): 1444 - 1450.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
A. Elhendy, E. L. O'Leary, F. Xie, A. C. McGrain, J. R. Anderson, and T. R. Porter
Comparative accuracy of real-time myocardial contrast perfusion imaging and wall motion analysis during dobutamine stress echocardiography for the diagnosis of coronary artery disease
J. Am. Coll. Cardiol., December 7, 2004; 44(11): 2185 - 2191.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EchocardiogrHome page
F. Frouin, A. Delouche, H. Raffoul, H. Diebold, E. Abergel, and B. Diebold
Factor analysis of the left ventricle by echocardiography (FALVE): a new tool for detecting regional wall motion abnormalities
Eur J Echocardiogr, October 1, 2004; 5(5): 335 - 346.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
M. V. Podgoreanu, G. N. Djaiani, E. Davis, B. Phillips-Bute, and J. P. Mathew
Quantitative Echocardiographic Assessment of Regional Wall Motion and Left Ventricular Asynchrony with Color Kinesis in Cardiac Surgery Patients
Anesth. Analg., May 1, 2003; 96(5): 1294 - 1300.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online