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Am J Physiol Heart Circ Physiol 280: H1793-H1801, 2001;
0363-6135/01 $5.00
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Vol. 280, Issue 4, H1793-H1801, April 2001

Sodium-induced rise in blood pressure is suppressed by androgen receptor blockade

Ann Caplea, Darcie Seachrist, Gail Dunphy, and Daniel Ely

Department of Biology, The University of Akron, Akron, Ohio 44325-3908

Our objective was to test the hypothesis that 1) a high Na (HNa, 3%) diet would increase blood pressure (BP) in male Wistar-Kyoto (WKY) and spontaneously hypertensive Y chromosome (SHR/y) rat strains in a territorial colony; 2) sympathetic nervous system (SNS) blockade using clonidine would lower BP on a HNa diet; and 3) prepubertal androgen receptor blockade with flutamide would lower BP on a HNa diet. A 2 × 4 factorial design used rat strains (WKY, SHR/y) and treatment [0.3% normal Na (NNa), 3% HNa, HNa/clonidine, and HNa/flutamide]. BP increased in both strains on the HNa diet (P < 0.0001). There was no significant decrease in BP in either strain with clonidine treatment. Androgen receptor blockade with flutamide significantly decreased BP in both strains (P < 0.0001) and normalized BP in the SHR/y colony. Neither heart rate nor activity could explain these BP differences. In conclusion, a Na sensitivity was observed in both strains, which was reduced to normotensive values by androgen blockade but not by SNS blockade.

hypertension; testosterone; salt; territorial stress; clonidine; sympathetic nervous system; flutamide; kidney


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