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Am J Physiol Heart Circ Physiol 280: H1807-H1813, 2001;
0363-6135/01 $5.00
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Vol. 280, Issue 4, H1807-H1813, April 2001

Regulation of extracellular volume and interstitial fluid pressure in rat bone marrow

Per Ole Iversen2, Ellen Berggreen1, Gunnar Nicolaysen3, and Karin Heyeraas1

1 Department of Physiology, University of Bergen, 5009 Bergen; 2 Institute for Nutrition Research and 3 Department of Physiology, University of Oslo, 0316 Oslo, Norway

The volume and fluid pressure characteristics of the intact bone marrow is incompletely understood. We used microspheres and lipoproteins for measurements of intravascular volume (IVV) and EDTA for interstitial fluid volume (IFV) within the rat bone marrow. Interstitial fluid pressure (IFP) was determined with micropipettes connected to a servo-controlled counter-pressure system. Both the microspheres and the lipoproteins yielded estimates of IVV of ~1 ml/100 g. After a brief reactive hyperemia, IVV increased to 2.5 ml/100 g, whereas IFV decreased with ~1.5 ml/100 g, so that total extracellular volume did not change. Baseline bone marrow IFP was 9.7 mmHg. The hyperemia led to a transient twofold increase in IFP, whereas a marked blood loss decreased IFP by almost one-half. These novel data suggest that extracellular volume and IFP within the bone marrow can be measured with tracer methods and the micropuncture technique. The responses of IVV, IFV, and IFP during changes in blood flow to the bone marrow suggest a tight regulation and are thus compatible with those for a low-compliant tissue.

compliance; extravascular volume; micropuncture technique


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