| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
is not necessary for cardiac
hypertrophy
1 Section of Cardiology, Department of Medicine, University of Illinois at Chicago, Illinois 60612; and 2 Max Planck Institut für Immunbiologie, Freiburg D-79011, Germany
Studies in
human and rodent models have shown that activation of protein kinase
C-
(PKC-) is associated with the development of pathological
hypertrophy, suggesting that ablation of the PKC- pathway might
prevent or reverse cardiac hypertrophy. To explore this, we studied
mice with targeted disruption of the PKC- gene (knockout, KO). There
were no detectable differences in expression or distribution of other
PKC isoforms between the KO and control hearts as determined by Western
blot analysis. Baseline hemodynamics were measured using a closed-chest
preparation and there were no differences in heart rate and arterial or
left ventricular pressure. Mice were subjected to two independent
hypertrophic stimuli: phenylephrine (Phe) at 20 mg · kg
1 · day1 sq infusion
for 3 days, and aortic banding (AoB) for 7 days. KO animals
demonstrated an increase in heart weight-to-body weight ratio (Phe,
4.3 ± 0.6 to 6.1 ± 0.4; AoB, 4.0 ± 0.1 to 5.8 ± 0.7) as well as ventricular upregulation of atrial natriuretic factor mRNA analogous to those seen in control animals. These results demonstrate that PKC- expression is not necessary for the
development of cardiac hypertrophy nor does its absence attenuate the
hypertrophic response.
transgenic mouse; LacZ; cell signaling
This article has been cited by other articles:
|
|
 |
|
  W. Soesanto, H.-y. Lin, E. Hu, S. Lefler, S. E. Litwin, S. Sena, E. D. Abel, J. D. Symons, and T. Jalili Mammalian Target of Rapamycin Is a Critical Regulator of Cardiac Hypertrophy in Spontaneously Hypertensive Rats Hypertension, December 1, 2009; 54(6): 1321 - 1327. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Liu, X. Chen, S. M. MacDonnell, E. G. Kranias, J. N. Lorenz, M. Leitges, S. R. Houser, and J. D. Molkentin Protein Kinase C{alpha}, but Not PKC{beta} or PKC{gamma}, Regulates Contractility and Heart Failure Susceptibility: Implications for Ruboxistaurin as a Novel Therapeutic Approach Circ. Res., July 17, 2009; 105(2): 194 - 200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Palaniyandi, L. Sun, J. C. B. Ferreira, and D. Mochly-Rosen Protein kinase C in heart failure: a therapeutic target? Cardiovasc Res, May 1, 2009; 82(2): 229 - 239. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Sorokina, J. M. O'Donnell, R. D. McKinney, K. M. Pound, G. Woldegiorgis, K. F. LaNoue, K. Ballal, H. Taegtmeyer, P. M. Buttrick, and E. D. Lewandowski Recruitment of Compensatory Pathways to Sustain Oxidative Flux With Reduced Carnitine Palmitoyltransferase I Activity Characterizes Inefficiency in Energy Metabolism in Hypertrophied Hearts Circulation, April 17, 2007; 115(15): 2033 - 2041. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Y. Boateng, R. J. Belin, D. L. Geenen, K. B. Margulies, J. L. Martin, M. Hoshijima, P. P. de Tombe, and B. Russell Cardiac dysfunction and heart failure are associated with abnormalities in the subcellular distribution and amounts of oligomeric muscle LIM protein Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H259 - H269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Takahashi, K. Okumura, T. Asai, T. Hirai, H. Murakami, R. Murakami, Y. Numaguchi, H. Matsui, M. Ito, and T. Murohara Dietary fish oil attenuates cardiac hypertrophy in lipotoxic cardiomyopathy due to systemic carnitine deficiency Cardiovasc Res, November 1, 2005; 68(2): 213 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N. Tsoporis, A. Marks, L. J. Van Eldik, D. O'Hanlon, and T. G. Parker Regulation of the S100B gene by alpha 1-adrenergic stimulation in cardiac myocytes Am J Physiol Heart Circ Physiol, January 1, 2003; 284(1): H193 - H203. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Ma, P. E. Kudlacek, and S. C. Sansom Protein kinase Calpha participates in activation of store-operated Ca2+ channels in human glomerular mesangial cells Am J Physiol Cell Physiol, November 1, 2002; 283(5): C1390 - C1398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. U Braun, P. LaRosee, S. Schon, M. M Borst, and R. H Strasser Differential regulation of cardiac protein kinase C isozyme expression after aortic banding in rat Cardiovasc Res, October 1, 2002; 56(1): 52 - 63. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Braz, O. F. Bueno, L. J. De Windt, and J. D. Molkentin PKC{alpha} regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1/2 (ERK1/2) J. Cell Biol., March 4, 2002; 156(5): 905 - 919. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. F Bueno, E. van Rooij, J. D Molkentin, P. A Doevendans, and L. J De Windt Calcineurin and hypertrophic heart disease: novel insights and remaining questions Cardiovasc Res, March 1, 2002; 53(4): 806 - 821. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Braz, O. F. Bueno, L. J. De Windt, and J. D. Molkentin PKC{alpha} regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1/2 (ERK1/2) J. Cell Biol., March 4, 2002; 156(5): 905 - 919. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
