| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Minerva Institute for Medical Research, Departments of 2 Medicine and 5 Clinical Chemistry, Helsinki University Central Hospital, Helsinki FIN-00029; and Departments of 3 Anatomy, 4 Medicine, and 6 Pathology, University of Turku, Turku FIN-20520, Finland
We investigated the role of cardiomyocyte apoptosis in the remodeling of the left ventricle from 24 h to 12 wk after myocardial infarction in the rat. Infarct size planimetry, quantification of cardiomyocyte apoptosis, terminal deoxynucleotide transferase-mediated dUTP nick-end labeling (TUNEL) methodology, and echocardiography (left ventricular diastolic diameter and ejection fraction) were performed. Sham-operated animals showed low rates of cardiomyocyte apoptosis (0.03%) and no change in diastolic diameter or ejection fraction during the study. Twenty-four hours after infarction, TUNEL positivity was high in the infarct areas (1.4%) and border zones (4.9%). It declined to 0.34% (P < 0.01 vs. sham) at 4 wk and 0.10% at 12 wk in the border zones. In the remote myocardium, cardiomyocyte apoptosis increased to 0.07% (P = 0.03 vs. sham) on day 1 and remained on the same level up to 4 wk. The increase in diastolic diameter 1-4 wk after infarction correlated (r = 0.60, P < 0.01) with cardiomyocyte apoptosis in the noninfarcted myocardium, which quantitatively contributed most (>50%) to the apoptotic cell loss by 4 wk.
ischemia
This article has been cited by other articles:
|
|
 |
|
  M. Park, Y.-T. Shen, V. Gaussin, G. R. Heyndrickx, J. Bartunek, R. R. G. Resuello, F. F. Natividad, R. N. Kitsis, D. E. Vatner, and S. F. Vatner Apoptosis predominates in nonmyocytes in heart failure Am J Physiol Heart Circ Physiol, August 1, 2009; 297(2): H785 - H791. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Dhanasekaran, S. K. Gruenloh, J. N. Buonaccorsi, R. Zhang, G. J. Gross, J. R. Falck, P. K. Patel, E. R. Jacobs, and M. Medhora Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H724 - H735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Lygate Letter to the editor: Infarct size measurements are critically important when comparing interventions affecting ventricular remodeling Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H3221 - H3221. [Full Text] [PDF]
|
|
|
|
 |
|
 L. Liu, X. Zhang, B. Qian, X. Min, X. Gao, C. Li, Y. Cheng, and J. Huang Over-expression of heat shock protein 27 attenuates doxorubicin-induced cardiac dysfunction in mice Eur J Heart Fail, August 1, 2007; 9(8): 762 - 769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Bak, I. Lekli, B. Juhasz, N. Nagy, E. Varga, J. Varadi, R. Gesztelyi, G. Szabo, L. Szendrei, I. Bacskay, et al. Cardioprotective mechanisms of Prunus cerasus (sour cherry) seed extract against ischemia-reperfusion-induced damage in isolated rat hearts Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1329 - H1336. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Matsushima, T. Ide, M. Yamato, H. Matsusaka, F. Hattori, M. Ikeuchi, T. Kubota, K. Sunagawa, Y. Hasegawa, T. Kurihara, et al. Overexpression of Mitochondrial Peroxiredoxin-3 Prevents Left Ventricular Remodeling and Failure After Myocardial Infarction in Mice Circulation, April 11, 2006; 113(14): 1779 - 1786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Jegger, X. Jeanrenaud, M. Nasratullah, P.-G. Chassot, A. Mallik, H. Tevaearai, L. K. von Segesser, P. Segers, and N. Stergiopulos Noninvasive Doppler-derived myocardial performance index in rats with myocardial infarction: validation and correlation by conductance catheter Am J Physiol Heart Circ Physiol, April 1, 2006; 290(4): H1540 - H1548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. Crow, K. Mani, Y.-J. Nam, and R. N. Kitsis The Mitochondrial Death Pathway and Cardiac Myocyte Apoptosis Circ. Res., November 12, 2004; 95(10): 957 - 970. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. See, W. Thomas, K. Way, A. Tzanidis, A. Kompa, D. Lewis, S. Itescu, and H. Krum p38 mitogen-activated protein kinase inhibition improves cardiac function and attenuates left ventricular remodeling following myocardial infarction in the rat J. Am. Coll. Cardiol., October 19, 2004; 44(8): 1679 - 1689. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Patten, I. Pourati, M. J. Aronovitz, J. Baur, F. Celestin, X. Chen, A. Michael, S. Haq, S. Nuedling, C. Grohe, et al. 17{beta}-Estradiol Reduces Cardiomyocyte Apoptosis In Vivo and In Vitro via Activation of Phospho-Inositide-3 Kinase/Akt Signaling Circ. Res., October 1, 2004; 95(7): 692 - 699. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Depre, S.-J. Kim, A. S. John, Y. Huang, O. E. Rimoldi, J. R. Pepper, G. D. Dreyfus, V. Gaussin, D. J. Pennell, D. E. Vatner, et al. Program of Cell Survival Underlying Human and Experimental Hibernating Myocardium Circ. Res., August 20, 2004; 95(4): 433 - 440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Schuster, A. A. Kocher, T. Seki, T. P. Martens, G. Xiang, S. Homma, and S. Itescu Myocardial neovascularization by bone marrow angioblasts results in cardiomyocyte regeneration Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H525 - H532. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. M. Yarbrough, R. Mukherjee, G. P. Escobar, J. A. Sample, J. E. McLean, K. B. Dowdy, J. W. Hendrick, W. C. Gibson, A. E. Hardin, J. T. Mingoia, et al. Pharmacologic inhibition of intracellular caspases after myocardial infarction attenuates left ventricular remodeling: a potentially novel pathway J. Thorac. Cardiovasc. Surg., December 1, 2003; 126(6): 1892 - 1899. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Mani and R. N. Kitsis Myocyte apoptosis: programming ventricular remodeling J. Am. Coll. Cardiol., March 5, 2003; 41(5): 761 - 764. [Full Text] [PDF]
|
|
|
|
 |
|
 F. Rademakers, F. Van de Werf, L. Mortelmans, G. Marchal, and J. Bogaert Evolution of regional performance after an acute anterior myocardial infarction in humans using magnetic resonance tagging J. Physiol., February 1, 2003; 546(3): 777 - 787. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Linke, W. Li, H. Huang, Z. Wang, and T. H. Hintze Role of cardiac eNOS expression during pregnancy in the coupling of myocardial oxygen consumption to cardiac work Am J Physiol Heart Circ Physiol, September 1, 2002; 283(3): H1208 - H1214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. N. Sharikabad, K. M. Ostbye, and O. Brors Increased [Mg2+]o reduces Ca2+ influx and disruption of mitochondrial membrane potential during reoxygenation Am J Physiol Heart Circ Physiol, November 1, 2001; 281(5): H2113 - H2123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Hare Oxidative Stress and Apoptosis in Heart Failure Progression Circ. Res., August 3, 2001; 89(3): 198 - 200. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
