| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of Internal Medicine and Physiology, Hunter Holmes McGuire Department of Veterans Affairs Medical Center, Richmond 23249; and Medical College of Virginia at Virginia Commonwealth University, Richmond, Virginia 23284
Clinicians and experimentalists routinely estimate
vagal-cardiac nerve traffic from respiratory sinus arrhythmia. However, evidence suggests that sympathetic mechanisms may also modulate respiratory sinus arrhythmia. Our study examined modulation of respiratory sinus arrhythmia by sympathetic outflow. We measured R-R
interval spectral power in 10 volunteers that breathed sequentially at
13 frequencies, from 15 to 3 breaths/min, before and after 
-adrenergic blockade. We fitted changes of respiratory frequency R-R
interval spectral power with a damped oscillator model:
frequency-dependent oscillations with a resonant frequency, generated
by driving forces and modified by damping influences. -Adrenergic
blockade enhanced respiratory sinus arrhythmia at all frequencies (at
some, fourfold). The damped oscillator model fit experimental
data well (39 of 40 ramps; r = 0.86 ± 0.02).
-Adrenergic blockade increased respiratory sinus arrhythmia by
amplifying respiration-related driving forces (P < 0.05), without altering resonant frequency or damping influences. Both
spectral power data and the damped oscillator model indicate that
cardiac sympathetic outflow markedly reduces heart period oscillations
at all frequencies. This challenges the notion that respiratory sinus
arrhythmia is mediated simply by vagal-cardiac nerve activity. These
results have important implications for clinical and experimental
estimation of human vagal cardiac tone.
autonomic nervous system; heart rate variability; vagus
This article has been cited by other articles:
|
|
 |
|
  J. P. Fisher, A. Kim, C. N. Young, S. Ogoh, P. B. Raven, N. H. Secher, and P. J. Fadel Influence of ageing on carotid baroreflex peak response latency in humans J. Physiol., November 15, 2009; 587(22): 5427 - 5439. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. E. Billman Cardiac autonomic neural remodeling and susceptibility to sudden cardiac death: effect of endurance exercise training Am J Physiol Heart Circ Physiol, October 1, 2009; 297(4): H1171 - H1193. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. C. Tzeng, P. Y. W. Sin, S. J. E. Lucas, and P. N. Ainslie Respiratory modulation of cardiovagal baroreflex sensitivity J Appl Physiol, September 1, 2009; 107(3): 718 - 724. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. C. Tzeng, P. Y. W. Sin, and D. C. Galletly Human sinus arrhythmia: inconsistencies of a teleological hypothesis Am J Physiol Heart Circ Physiol, January 1, 2009; 296(1): H65 - H70. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Takahashi, K. Matsukawa, T. Nakamoto, H. Tsuchimochi, A. Sakaguchi, K. Kawaguchi, and K. Onari Control of heart rate variability by cardiac parasympathetic nerve activity during voluntary static exercise in humans with tetraplegia J Appl Physiol, November 1, 2007; 103(5): 1669 - 1677. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhong, Y. Bai, B. Yang, K. Ju, K. Shin, M. Lee, K.-M. Jan, and K. H. Chon Autonomic nervous nonlinear interactions lead to frequency modulation between low- and high-frequency bands of the heart rate variability spectrum Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2007; 293(5): R1961 - R1968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. C. Tzeng, P. D. Larsen, and D. C. Galletly Effects of hypercapnia and hypoxemia on respiratory sinus arrhythmia in conscious humans during spontaneous respiration Am J Physiol Heart Circ Physiol, May 1, 2007; 292(5): H2397 - H2407. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Nelson and G. A. Iwamoto Reversibility of exercise-induced dendritic attenuation in brain cardiorespiratory and locomotor areas following exercise detraining J Appl Physiol, October 1, 2006; 101(4): 1243 - 1251. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Malliani, C. Julien, G. E. Billman, S. Cerutti, M. F. Piepoli, L. Bernardi, P. Sleight, M. A. Cohen, C. O. Tan, D. Laude, et al. Cardiovascular variability is/is not an index of autonomic control of circulation J Appl Physiol, August 1, 2006; 101(2): 684 - 688. [Full Text] [PDF]
|
|
|
|
|
|
G. Parati, G. Mancia, M. D. Rienzo, P. Castiglioni, J. A. Taylor, and P. Studinger Cardiovascular variability is/is not an index of autonomic control of circulation. J Appl Physiol, August 1, 2006; 101(2): 690 - 691. [Full Text] [PDF]
|
|
|
|
|
|
G. Parati, G. Mancia, M. D. Rienzo, P. Castiglioni, J. A. Taylor, and P. Studinger Point:Counterpoint: Cardiovascular variability is/is not an index of autonomic control of circulation J Appl Physiol, August 1, 2006; 101(2): 676 - 682. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ogoh, J. P Fisher, E. A Dawson, M. J White, N. H Secher, and P. B Raven Autonomic nervous system influence on arterial baroreflex control of heart rate during exercise in humans J. Physiol., July 15, 2005; 566(2): 599 - 611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. L. Smith, M. Kukielka, and G. E. Billman Heart rate recovery after exercise: a predictor of ventricular fibrillation susceptibility after myocardial infarction Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1763 - H1769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Hamner, M. A. Cohen, S. Mukai, L. A. Lipsitz, and J. A. Taylor Spectral indices of human cerebral blood flow control: responses to augmented blood pressure oscillations J. Physiol., September 15, 2004; 559(3): 965 - 973. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Cysarz, D. von Bonin, H. Lackner, P. Heusser, M. Moser, and H. Bettermann Oscillations of heart rate and respiration synchronize during poetry recitation Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H579 - H587. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Grossman, F. H. Wilhelm, and M. Spoerle Respiratory sinus arrhythmia, cardiac vagal control, and daily activity Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H728 - H734. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Lamine, P. Calabrese, H. Perrault, T. P. Dinh, A. Eberhard, and G. Benchetrit Individual differences in respiratory sinus arrhythmia Am J Physiol Heart Circ Physiol, June 1, 2004; 286(6): H2305 - H2312. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. E. Cooper, T. H. Clutton-Brock, and M. J. Parkes Contribution of the respiratory rhythm to sinus arrhythmia in normal unanesthetized subjects during positive-pressure mechanical hyperventilation Am J Physiol Heart Circ Physiol, January 1, 2004; 286(1): H402 - H411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. D. Giardino, R. W. Glenny, S. Borson, and L. Chan Respiratory sinus arrhythmia is associated with efficiency of pulmonary gas exchange in healthy humans Am J Physiol Heart Circ Physiol, May 1, 2003; 284(5): H1585 - H1591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L Eckberg The human respiratory gate J. Physiol., April 15, 2003; 548(2): 339 - 352. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Toledo, O. Gurevitz, H. Hod, M. Eldar, and S. Akselrod Wavelet analysis of instantaneous heart rate: a study of autonomic control during thrombolysis Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2003; 284(4): R1079 - R1091. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A Cohen and J A. Taylor Short-term cardiovascular oscillations in man: measuring and modelling the physiologies J. Physiol., August 1, 2002; 542(3): 669 - 683. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Kaushal and J. A. Taylor Inter-relations among declines in arterial distensibility, baroreflex function and respiratory sinus arrhythmia J. Am. Coll. Cardiol., May 1, 2002; 39(9): 1524 - 1530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Malpas Neural influences on cardiovascular variability: possibilities and pitfalls Am J Physiol Heart Circ Physiol, January 1, 2002; 282(1): H6 - H20. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
