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1 Departments of Medical Biophysics, 2 Anaesthesia, and 3 Respirology, University of Western Ontario, London, Ontario N6A 5B8, Canada; and 4 Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, Saint Louis, Missouri 63104
Erythrocyte
deformability has been recognized as a determinant of microvascular
perfusion. Because nitric oxide (NO) is implicated in the modulation of
red blood cell (RBC) deformability and NO levels increase during
sepsis, we tested the hypothesis that a NO-mediated decrease in RBC
deformability contributes to decreased functional capillary density
(CD) in remote organs. With the use of a peritonitis model of sepsis in
the rat [cecal ligation and perforation (CLP)] and aminoguanidine
(AG) to prevent increases in NO, we measured CD in skeletal muscle
(intravital microscopy), mean erythrocyte membrane deformability
(
microcirculation; abnormalities; septicemia; functional capillary density
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