AJP - Heart Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 281: H124-H131, 2001;
0363-6135/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (15)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chen, L.
Right arrow Articles by Hedenstierna, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chen, L.
Right arrow Articles by Hedenstierna, G.
Vol. 281, Issue 1, H124-H131, July 2001

Endothelin-1 and nitric oxide synthase in short rebound reaction to short exposure to inhaled nitric oxide

Luni Chen1, Hao He1, Enrique Fernandez Mondejar1, Filip Fredén2, Peter Wiklund3, Kjell Alving4, and Göran Hedenstierna1

1 Department of Clinical Physiology and 2 Department of Anesthesiology and Intensive Care, University Hospital, S-75185 Uppsala; and 3 Department of Urology and 4 Department of Physiology and Pharmacology, Karolinska Institute, S-17176 Stockholm, Sweden

On withdrawal of inhalation of nitric oxide (INO) administered after lung injury, pulmonary artery pressure (PAP) and arterial oxygen tension (PaO2) may deteriorate more than before INO (rebound response). In this study, we investigated the possible roles of endothelin (ET)-1 and nitric oxide (NO) synthase (NOS) activity in the short rebound reaction to short-term inhalation of NO. Twenty-six anesthetized mechanically ventilated piglets were given endotoxin infusion. Twelve animals then received INO (30 parts per million) for two 30-min periods. Nine controls were not given NO. Measurements were made of blood gases and hemodynamic parameters, lung tissue ET-1 expression and NOS activity, and plasma ET-1 concentration. INO decreased PAP and increased PaO2, but INO withdrawal caused a short rebound reaction with an increase in PAP. Lung tissue expression and plasma concentration of ET-1 increased during INO, and plasma ET-1 increased further after its withdrawal. Activity of constitutive NOS decreased during INO, whereas that of inducible NOS was unchanged. Upregulation of ET-1 and downregulation of NOS activity may have influenced the short rebound reaction to short-term INO.

endotoxin


This article has been cited by other articles:


Home page
 NEJMHome page
M. J.D. Griffiths and T. W. Evans
Inhaled Nitric Oxide Therapy in Adults
N. Engl. J. Med., December 22, 2005; 353(25): 2683 - 2695.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
L. K. Kelly, S. Wedgwood, R. H. Steinhorn, and S. M. Black
Nitric oxide decreases endothelin-1 secretion through the activation of soluble guanylate cyclase
Am J Physiol Lung Cell Mol Physiol, May 1, 2004; 286(5): L984 - L991.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. Gerlach, D. Keh, A. Semmerow, T. Busch, K. Lewandowski, D. M. Pappert, R. Rossaint, and K. J. Falke
Dose-Response Characteristics during Long-Term Inhalation of Nitric Oxide in Patients with Severe Acute Respiratory Distress Syndrome: A Prospective, Randomized, Controlled Study
Am. J. Respir. Crit. Care Med., April 1, 2003; 167(7): 1008 - 1015.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
L. Chen, H. He, E. F. Mondejar, and G. Hedenstierna
Cyclooxygenase inhibitor blocks rebound response after NO inhalation in an endotoxin model
Am J Physiol Heart Circ Physiol, January 1, 2003; 284(1): H290 - H298.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online