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Am J Physiol Heart Circ Physiol 281: H342-H349, 2001;
0363-6135/01 $5.00
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Vol. 281, Issue 1, H342-H349, July 2001

Cysteinyl leukotrienes mediate enhanced vasoconstriction to angiotensin II but not endothelin-1 in SHR

Shailesh Shastri1, J. Robert McNeill2, Thomas W. Wilson2, Ramarao Poduri1, Chamanlal Kaul1, and Venkat Gopalakrishnan2

1 Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education & Research, SAS Nagar, 160 062, India; and 2 Department of Pharmacology and the Cardiovascular Risk Factor Reduction Unit, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada

We assessed whether cysteinyl leukotrienes mediate the vasoconstrictor responses to angiotensin II and endothelin-1 in the mesenteric vascular bed of Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) perfused ex vivo at a constant flow rate of 5 ml/min with Krebs buffer. Maximal perfusion pressure response (Emax) but not EC50 values to angiotensin II (P < 0.001) and endothelin-1 (P < 0.01) were significantly higher in the SHR, whereas the responses to potassium chloride remained unchanged. Inclusion of the selective 5-lipoxygenase inhibitor AA-861 or the cysteinyl leukotriene receptor antagonist MK-571 significantly reduced the vasoconstrictor responses to angiotensin II but not to endothelin-1 and potassium chloride. The reduction in Emax to angiotensin II was more pronounced in SHR (P < 0.001) than in WKY (P < 0.05) rats. Cysteinyl leukotrienes LTC4-, LTD4-, and LTE4 (1 µM)-evoked vasoconstrictor responses were significantly higher in SHR (P < 0.05), whereas LTB4 failed to evoke any response in either strain. These data suggest that 5-lipoxygenase metabolites, particularly cysteinyl leukotrienes, contribute to the exaggerated vasoconstrictor responses to angiotensin II but not to endothelin-1.

lipoxygenase; mesenteric vascular bed; spontaneously hypertensive rats


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P. Liu, D. A. Misurski, and V. Gopalakrishnan
Cysteinyl leukotriene-dependent [Ca2+]i responses to angiotensin II in cardiomyocytes
Am J Physiol Heart Circ Physiol, April 1, 2003; 284(4): H1269 - H1276.
[Abstract] [Full Text] [PDF]


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