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Am J Physiol Heart Circ Physiol 281: H457-H462, 2001;
0363-6135/01 $5.00
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Vol. 281, Issue 1, H457-H462, July 2001

RAPID COMMUNICATION
Expression of metabotropic glutamate receptors in nodose ganglia and the nucleus of the solitary tract

Caroline J. Hoang and Meredith Hay

Dalton Cardiovascular Research Center and Department of Veterinary Biomedical Sciences, University of Missouri at Columbia, Columbia, Missouri 65211

The purpose of this study was to identify the complement of metabotropic glutamate receptors (mGluRs) expressed in nodose ganglia and the nucleus tractus solitarius (NTS). mRNA from these tissues was isolated and amplified with standard RT-PCR with primers specific for each mGluR subtype. The results of this analysis showed that the NTS expresses all eight mGluR subtypes, whereas nodose ganglia express only group III mGluRs: mGluR4, mGluR6, mGluR7, and mGluR8. Application of the group III-specific mGluR agonist L-(+)-2-amino-4-phosphonobutyric acid (100 µM) reversibly inhibited voltage-gated calcium currents isolated from DiI-labeled aortic baroreceptor neurons and unlabeled nodose neurons. The results of this study suggest that group III mGluRs are the primary mGluR subtype expressed in visceral afferent neurons and that these receptors may be involved in afferent central transmission.

nodose neurons; baroreceptors; L-(+)-amino-4-phosphonobutyric acid


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