AJP - Heart Calcium Transients and Cell-Sarcomere
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 281: H573-H580, 2001;
0363-6135/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (9)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tabata, T.
Right arrow Articles by Thomas, J. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tabata, T.
Right arrow Articles by Thomas, J. D.
Vol. 281, Issue 2, H573-H580, August 2001

Assessment of LV systolic function in atrial fibrillation using an index of preceding cardiac cycles

Tomotsugu Tabata1, Richard A. Grimm1, Neil L. Greenberg1, Deborah A. Agler1, Kent A. Mowrey2, Don W. Wallick2, Youhua Zhang2, Shaowei Zhuang2, Todor N. Mazgalev2, and James D. Thomas1

Sections of 1 Cardiovascular Imaging and 2 Electrophysiology, Department of Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195

The clinical assessment of left ventricular (LV) systolic function during atrial fibrillation (AF) is unreliable and difficult because of beat-to-beat variability. We evaluated an index for the estimation of LV systolic function in AF that is based on the relationship between the preceding (R-R1) and prepreceding (R-R2) R-R intervals. LV Doppler stroke volume (SV), ejection fraction (EF), peak aortic flow rate (AoF) and the maximum value of the first derivative of the LV pressure curve (dP/dtmax) were evaluated in 13 healthy open-chest dogs during triggered AF. All parameters showed a significantly strong positive linear relationship with the ratio of R-R1/R-R2 (r = 0.65, 0.74, 0.75, and 0.70 for SV, EF, AoF, and dP/dtmax, respectively). The calculated value of LV systolic parameters at R-R1/R-R2 = 1 in the linear regression line showed a good relationship and an agreement with the measured average value of the parameter over all cardiac cycles (SV, 12.1 vs. 12.8 ml; EF, 49.6 vs. 51.2%; AoF, 1.37 vs. 1.48 l/min; and dP/dtmax, 2,323 vs. 2,454 mmHg/s). Using the LV systolic parameters estimated at R-R1/R-R2 = 1 in the linear regression line allows the LV contractile function to be accurately and reproducibly evaluated during AF and obviates the less-reliable process of averaging multiple cardiac cycles.

preload; afterload; contractility; R-R interval; echocardiography; left ventricular


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. Tabata, R. A. Grimm, J. Asada, Z. B. Popovic, H. Yamada, N. L. Greenberg, D. W. Wallick, Y. Zhang, S. Zhuang, K. A. Mowrey, et al.
Determinants of LV diastolic function during atrial fibrillation: beat-to-beat analysis in acute dog experiments
Am J Physiol Heart Circ Physiol, January 1, 2004; 286(1): H145 - H152.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Z. B. Popovic', K. A. Mowrey, Y. Zhang, S. Zhuang, T. Tabata, D. W. Wallick, R. A. Grimm, J. D. Thomas, and T. N. Mazgalev
Slow rate during AF improves ventricular performance by reducing sensitivity to cycle length irregularity
Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2706 - H2713.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online