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Am J Physiol Heart Circ Physiol 281: H939-H950, 2001;
0363-6135/01 $5.00
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Vol. 281, Issue 2, H939-H950, August 2001

Effects of erythrocyte aggregation and venous network geometry on red blood cell axial migration

Jeffrey J. Bishop1, Aleksander S. Popel2, Marcos Intaglietta1, and Paul C. Johnson1

1 Department of Bioengineering, University of California, San Diego, La Jolla, California 92093-0412; and 2 Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205

Axial migration of red blood cells in small glass tubes can cause blood viscosity to be effectively independent of shear rate. However, this phase separation may not occur to the same degree in the venous network due to infusion of cells and aggregates at branch points. To investigate this hypothesis, we followed trajectories of fluorescently labeled red blood cells in the venular network of the rat spinotrapezius muscle at normal and reduced flow with and without red blood cell aggregation. Cells traveling near the wall of an unbranched venular segment migrated ~1% of the longitudinal path length without aggregation and migrated slightly more with aggregation. Venular segment length between branch points averaged three to five times the diameter. Cells in the main vessel were shifted centrally by up to 20% of diameter at branch points, reducing the migration rate of cells near the opposite wall to <1% even in the presence of aggregation. We conclude that formation of a cell-free marginal layer in the venular network is attenuated due to the time dependence of axial migration and the frequent branching of the network.

venous resistance; radial migration; red blood cell aggregation; in vivo fluorescence microscopy; venous network topology


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