AJP - Heart AJP citation statistics
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 281: H975-H980, 2001;
0363-6135/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (31)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Xu, H.
Right arrow Articles by Galligan, J. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Xu, H.
Right arrow Articles by Galligan, J. J.
Vol. 281, Issue 2, H975-H980, August 2001

RAPID COMMUNICATION
Nitric oxide-independent effects of tempol on sympathetic nerve activity and blood pressure in normotensive rats

Hui Xu, Gregory D. Fink, Alex Chen, Stephanie Watts, and James J. Galligan

Department of Pharmacology and Toxicology and Neuroscience Program, Michigan State University, East Lansing, Michigan 48824

The role of the sympathetic nervous system in 4-hydroxy-2,2,6,6-tetramethyl piperidinoxyl (tempol)-induced cardiovascular responses in urethane-anesthetized, normotensive rats was evaluated. Tempol caused dose-dependent (30-300 µmol/kg iv) decreases in renal sympathetic nerve activity (RSNA), mean arterial blood pressure (MAP), and heart rate (HR). Similar responses were obtained after sinoaortic denervation and cervical vagotomy. These responses were not blocked following treatment with the nitric oxide synthase inhibitor NG-nitro-L-arginine (2.6 mg · kg-1 · min-1 iv for 5 min) or the alpha 2-adrenergic receptor antagonist idazoxan (0.3 mg/kg iv bolus). Idazoxan blocked the effects of clonidine (10 µg/kg iv) on HR, MAP, and RSNA. Hexamethonium (30 mg/kg iv) inhibited RSNA, and tempol did not decrease RSNA after hexamethonium. The effects of tempol on HR and MAP were reduced by hexamethonium. In conclusion, depressor responses caused by tempol are mediated, partly, by sympathoinhibition in urethane-anesthetized, normotensive rats. Nitric oxide does not contribute to this response, and the sympathoinhibitory effect of tempol is not mediated via alpha 2-adrenergic receptors. Finally, tempol directly decreases HR, which may contribute to the MAP decrease.

sympathetic nervous system; NG-nitro-L-arginine


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. J. Chess, W. Xu, R. Khairallah, K. M. O'Shea, W. J. Kop, A. M. Azimzadeh, and W. C. Stanley
The antioxidant tempol attenuates pressure overload-induced cardiac hypertrophy and contractile dysfunction in mice fed a high-fructose diet
Am J Physiol Heart Circ Physiol, December 1, 2008; 295(6): H2223 - H2230.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
D. Liu, L. Gao, S. K. Roy, K. G. Cornish, and I. H. Zucker
Role of Oxidant Stress on AT1 Receptor Expression in Neurons of Rabbits With Heart Failure and in Cultured Neurons
Circ. Res., July 18, 2008; 103(2): 186 - 193.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
H. Xu, W. F. Jackson, G. D. Fink, and J. J. Galligan
Activation of Potassium Channels by Tempol in Arterial Smooth Muscle Cells From Normotensive and Deoxycorticosterone Acetate-Salt Hypertensive Rats
Hypertension, December 1, 2006; 48(6): 1080 - 1087.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
S. Ye, H. Zhong, and V. M. Campese
Oxidative Stress Mediates the Stimulation of Sympathetic Nerve Activity in the Phenol Renal Injury Model of Hypertension
Hypertension, August 1, 2006; 48(2): 309 - 315.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. Patel, Y. Chen, K. Dennehy, J. Blau, S. Connors, M. Mendonca, M. Tarpey, M. Krishna, J. B. Mitchell, W. J. Welch, et al.
Acute antihypertensive action of nitroxides in the spontaneously hypertensive rat
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2006; 290(1): R37 - R43.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
Y. E. Lau, J. J. Galligan, D. L. Kreulen, and G. D. Fink
Activation of ETB receptors increases superoxide levels in sympathetic ganglia in vivo
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2006; 290(1): R90 - R95.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
H. Xu, X. Bian, S. W. Watts, and A. Hlavacova
Activation of Vascular BK Channel by Tempol in DOCA-Salt Hypertensive Rats
Hypertension, November 1, 2005; 46(5): 1154 - 1162.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. S. Wilcox
Oxidative stress and nitric oxide deficiency in the kidney: a critical link to hypertension?
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2005; 289(4): R913 - R935.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
V. M. Campese, Y. Shaohua, and Z. Huiquin
Oxidative Stress Mediates Angiotensin II-Dependent Stimulation of Sympathetic Nerve Activity
Hypertension, September 1, 2005; 46(3): 533 - 539.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
L. Gao, W. Wang, Y.-L. Li, H. D. Schultz, D. Liu, K. G. Cornish, and I. H. Zucker
Sympathoexcitation by central ANG II: Roles for AT1 receptor upregulation and NAD(P)H oxidase in RVLM
Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2271 - H2279.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
N. Lu, B. G. Helwig, R. J. Fels, S. Parimi, and M. J. Kenney
Central Tempol alters basal sympathetic nerve discharge and attenuates sympathetic excitation to central ANG II
Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2626 - H2633.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
T. Shokoji, Y. Fujisawa, S. Kimura, M. Rahman, H. Kiyomoto, K. Matsubara, K. Moriwaki, Y. Aki, A. Miyatake, M. Kohno, et al.
Effects of Local Administrations of Tempol and Diethyldithio-Carbamic on Peripheral Nerve Activity
Hypertension, August 1, 2004; 44(2): 236 - 243.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
D. N. Mayorov, G. A. Head, and R. De Matteo
Tempol Attenuates Excitatory Actions of Angiotensin II in the Rostral Ventrolateral Medulla During Emotional Stress
Hypertension, July 1, 2004; 44(1): 101 - 106.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
H. A. Koomans, P. J. Blankestijn, and J. A. Joles
Sympathetic Hyperactivity in Chronic Renal Failure: A Wake-up Call
J. Am. Soc. Nephrol., March 1, 2004; 15(3): 524 - 537.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
H. Xu, G. D. Fink, and J. J. Galligan
Tempol Lowers Blood Pressure and Sympathetic Nerve Activity But Not Vascular O2- in DOCA-Salt Rats
Hypertension, February 1, 2004; 43(2): 329 - 334.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
E. R. Gross, J. F. LaDisa Jr., D. Weihrauch, L. E. Olson, T. T. Kress, D. A. Hettrick, P. S. Pagel, D. C. Warltier, and J. R. Kersten
Reactive oxygen species modulate coronary wall shear stress and endothelial function during hyperglycemia
Am J Physiol Heart Circ Physiol, May 1, 2003; 284(5): H1552 - H1559.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
T. Shokoji, A. Nishiyama, Y. Fujisawa, H. Hitomi, H. Kiyomoto, N. Takahashi, S. Kimura, M. Kohno, and Y. Abe
Renal Sympathetic Nerve Responses to Tempol in Spontaneously Hypertensive Rats
Hypertension, February 1, 2003; 41(2): 266 - 273.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. Xu, G. D. Fink, and J. J. Galligan
Nitric oxide-independent effects of tempol on sympathetic nerve activity and blood pressure in DOCA-salt rats
Am J Physiol Heart Circ Physiol, September 1, 2002; 283(3): H885 - H892.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online