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Am J Physiol Heart Circ Physiol 281: H1447-H1457, 2001;
0363-6135/01 $5.00
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Vol. 281, Issue 3, H1447-H1457, September 2001

SPECIAL COMMUNICATION
Microfocal X-ray CT imaging and pulmonary arterial distensibility in excised rat lungs

Kelly L. Karau1,3, Roger H. Johnson3, Robert C. Molthen1,3,4, Anita H. Dhyani3, Steven T. Haworth1, Christopher C. Hanger2, David L. Roerig2,4, and Christopher A. Dawson1,3,4

Departments of 1 Physiology and 2 Anesthesiology, Medical College of Wisconsin, Milwaukee 53226; 3 Department of Biomedical Engineering, Marquette University, Milwaukee 53201-1881; and 4 Research Service, Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53295

The objective of this study was to develop an X-ray computed tomographic method for measuring pulmonary arterial dimensions and locations within the intact rat lung. Lungs were removed from rats and their pulmonary arterial trees were filled with perfluorooctyl bromide to enhance X-ray absorbance. The lungs were rotated within the cone of the X-ray beam projected from a microfocal X-ray source onto an image intensifier, and 360 images were obtained at 1° increments. The three-dimensional image volumes were reconstructed with isotropic resolution using a cone beam reconstruction algorithm. The vessel diameters were obtained by fitting a functional form to the image of the vessel circular cross section. The functional form was chosen to take into account the point spread function of the image acquisition and reconstruction system. The diameter measurements obtained over a range of vascular pressures were used to characterize the distensibility of the rat pulmonary arteries. The distensibility coefficient alpha  [defined by D(P) = D(0)(1 + alpha P), where D(P) is the diameter at intravascular pressure (P)] was ~2.8% mmHg and independent of vessel diameter in the diameter range (about 100 to 2,000 mm) studied.

cone beam reconstruction; pulmonary arterial diameter; pulmonary blood flow distribution


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