| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Medical Physiology, Cardiovascular Research Institute, Texas A&M University System Health Science Center, College Station, Texas 77845; and 2 Department of Human Biology, Royal Melbourne Institute of Technology University, Bundoora, Victoria 3083, Australia
Ion channels are regulated by protein phosphorylation and
dephosphorylation of serine, threonine, and tyrosine residues. Evidence for the latter process, tyrosine phosphorylation, has increased substantially since this topic was last reviewed. In this review, we
present a comprehensive summary and synthesis of the literature regarding the mechanism and function of ion channel regulation by
protein tyrosine kinases and phosphatases. Coverage includes the
majority of voltage-gated, ligand-gated, and second messenger-gated channels as well as several types of channels that have not yet been
cloned, including store-operated Ca2+ channels,
nonselective cation channels, and epithelial Na+ and
Cl
channels. Additionally, we discuss the critical roles
that channel-associated scaffolding proteins may play in localizing
protein tyrosine kinases and phosphatases to the vicinity of ion channels.
receptor tyrosine kinase; nonreceptor tyrosine kinase; protein
tyrosine phosphatase; integrins; cytoskeleton; K+ channel; Ca2+ channel; Cl channel; ligand-gated
channel; Na+ channel; receptor-activated channel; calcium
release-activated current; focal adhesion; growth factors; scaffolding
proteins; Src; Fyn; Lck; Hck; A kinase-associated protein; PDZ; SH2; SH3; CFTR; MAGUK
This article has been cited by other articles:
|
|
 |
|
  W. Chen and R. A. Khalil Differential [Ca2+]i signaling of vasoconstriction in mesenteric microvessels of normal and reduced uterine perfusion pregnant rats Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2008; 295(6): R1962 - R1972. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Jeulin, V. Seltzer, D. Bailbe, K. Andreau, and F. Marano EGF mediates calcium-activated chloride channel activation in the human bronchial epithelial cell line 16HBE14o-: involvement of tyrosine kinase p60c-src Am J Physiol Lung Cell Mol Physiol, September 1, 2008; 295(3): L489 - L496. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Sjostrom, E. A. Rancz, A. Roth, and M. Hausser Dendritic Excitability and Synaptic Plasticity Physiol Rev, April 1, 2008; 88(2): 769 - 840. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Hinard, D. Belin, S. Konig, C. R. Bader, and L. Bernheim Initiation of human myoblast differentiation via dephosphorylation of Kir2.1 K+ channels at tyrosine 242 Development, March 1, 2008; 135(5): 859 - 867. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-H. Li, Q. Zhang, B. Teng, S. J. Mustafa, J.-Y. Huang, and H.-G. Yu Src tyrosine kinase alters gating of hyperpolarization-activated HCN4 pacemaker channel through Tyr531 Am J Physiol Cell Physiol, January 1, 2008; 294(1): C355 - C362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kang, G. R. Ross, and H. I. Akbarali COOH-terminal association of human smooth muscle calcium channel Cav1.2b with Src kinase protein binding domains: effect of nitrotyrosylation Am J Physiol Cell Physiol, December 1, 2007; 293(6): C1983 - C1990. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Abriel Roles and regulation of the cardiac sodium channel Nav1.5: Recent insights from experimental studies Cardiovasc Res, December 1, 2007; 76(3): 381 - 389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-S. Zhou, L.-B. Zhang, W.-P. Sun, F.-C. Xiao, Y.-M. Zhou, Y.-J. Li, and D.-L. Li Heart/Cardiac Muscle: Effects of monocarboxylic acid-derived Cl- channel blockers on depolarization-activated potassium currents in rat ventricular myocytes Exp Physiol, May 1, 2007; 92(3): 549 - 559. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Missan, P. Linsdell, and T. F. McDonald Tyrosine kinase and phosphatase regulation of slow delayed-rectifier K+ current in guinea-pig ventricular myocytes J. Physiol., June 1, 2006; 573(2): 469 - 482. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zong, C. Eckert, H. Yuan, C. Wahl-Schott, H. Abicht, L. Fang, R. Li, P. Mistrik, A. Gerstner, B. Much, et al. A Novel Mechanism of Modulation of Hyperpolarization-activated Cyclic Nucleotide-gated Channels by Src Kinase J. Biol. Chem., October 7, 2005; 280(40): 34224 - 34232. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Chittajallu, A. A. Aguirre, and V. Gallo Downregulation of Platelet-Derived Growth Factor-{alpha} Receptor-Mediated Tyrosine Kinase Activity as a Cellular Mechanism for K+-Channel Regulation during Oligodendrocyte Development In Situ J. Neurosci., September 21, 2005; 25(38): 8601 - 8610. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. I. Akbarali Signal-Transduction Pathways that Regulate Smooth Muscle Function II. Receptor-ion channel coupling mechanisms in gastrointestinal smooth muscle Am J Physiol Gastrointest Liver Physiol, April 1, 2005; 288(4): G598 - G602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ling, J.-Z. Sheng, and A. P. Braun The calcium-dependent activity of large-conductance, calcium-activated K+ channels is enhanced by Pyk2- and Hck-induced tyrosine phosphorylation Am J Physiol Cell Physiol, September 1, 2004; 287(3): C698 - C706. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Nesti, B. Everill, and A. D. Morielli Endocytosis as a Mechanism for Tyrosine Kinase-dependent Suppression of a Voltage-gated Potassium Channel Mol. Biol. Cell, September 1, 2004; 15(9): 4073 - 4088. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Jin, N. Morsy, J. Winston, P. J. Pasricha, K. Garrett, and H. I. Akbarali Modulation of TRPV1 by nonreceptor tyrosine kinase, c-Src kinase Am J Physiol Cell Physiol, August 1, 2004; 287(2): C558 - C563. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. V. Bobkov and B. W. Ache Calcium Sensitivity of a Sodium-Activated Nonselective Cation Channel in Lobster Olfactory Receptor Neurons J Neurophysiol, November 1, 2003; 90(5): 2928 - 2940. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Belevych, S. Warrier, and R. D. Harvey Genistein Inhibits Cardiac L-Type Ca2+ Channel Activity by a Tyrosine Kinase-Independent Mechanism Mol. Pharmacol., September 1, 2002; 62(3): 554 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Byron and P. A. Lucchesi Signal Transduction of Physiological Concentrations of Vasopressin in A7r5 Vascular Smooth Muscle Cells. A ROLE FOR PYK2 AND TYROSINE PHOSPHORYLATION OF K+ CHANNELS IN THE STIMULATION OF Ca2+ SPIKING J. Biol. Chem., February 22, 2002; 277(9): 7298 - 7307. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
