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Am J Physiol Heart Circ Physiol 281: H1913-H1918, 2001;
0363-6135/01 $5.00
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Vol. 281, Issue 5, H1913-H1918, November 2001

Microvascular pressure measurement reveals a coronary vascular waterfall in arterioles larger than 110 µm

J. Pieter Versluis, Johannes W. Heslinga, Pieter Sipkema, and Nico Westerhof

Laboratory for Physiology, Institute for Cardiovascular Research, Vrije Universiteit, 1081 BT Amsterdam, The Netherlands

Pressure-flow relationships at the entrance of the coronary circulation in the diastolic myocardium exhibit a zero-flow pressure intercept (Pint). We tested whether this intercept is the same throughout the vascular bed. Microvascular pressure-flow relationships were therefore measured in vessels of various sizes of the maximally dilated vasculature of perfused unstimulated papillary muscle using the servo-null technique. From these relationships, Pint were calculated with nonlinear regression. The Pint at the level of the septal artery (diameter, 150-250 µm) was 23.2 ± 4.4 cmH2O (n = 12). In arterioles with a diameter range between 24 and 110 µm, Pint was 1.7 ± 0.5 cmH2O (n = 6, P < 0.01), significantly lower than in the septal artery but significantly higher than zero, and not dependent on vessel size. In venules with the same diameters, Pint was 1.1 ± 1.1 cmH2O (n = 4), which was not different from zero. We conclude that, in the dilated vascular bed of the papillary muscle, two vascular waterfalls are found. The first waterfall is located in arterioles between 150 and 110 µm. The second waterfall is probably located in the small postcapillary venules.

rat; servo-null; FITC-dextran; coronary flow; microvasculature


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