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1 Department of Cardiology, Groot Ziekengasthuis, 5200 ME Den Bosch, The Netherlands; and 2 Program in Cardiovascular Sciences, Department of Physiology and Biophysics, University of Illinois, Chicago, Illinois 60612
We studied the effects of
chronic losartan (Los) treatment on contractile function of isolated
right ventricular (RV) trabeculae from rat hearts 12 wk after left
ventricular (LV) myocardial infarction (MI) had been induced by
ligation of the left anterior descending artery at 4 wk of age. After
recovery, one-half of the animals were started on Los treatment
(MI+Los; 30 mg · kg
1 · day1
per os); the remaining animals were not treated (MI group). Rats without infarction or Los treatment served as controls (Con group). MI
resulted in increases in LV and RV weight and unstressed LV cavity
diameter; these were partially prevented by Los treatment. The active
peak twitch force-sarcomere length relation was depressed in MI
compared with either Con or MI+Los. Likewise, maximum Ca2+
saturated twitch force was depressed in MI, whereas twitch relaxation and twitch duration were prolonged. Myofilament function, as measured in skinned trabeculae, was not significantly different among the Con,
MI, and MI+Los groups. We conclude that Los prevents contractile dysfunction in rat RV trabeculae after LV MI. Our results suggest that
the beneficiary effect of Los treatment results not from improved
myofilament function but rather from improved myocyte Ca2+ homeostasis.
heart failure; ventricular hypertrophy; angiotensin II type I receptor blocker; skinned fiber; Ca2+ sensitivity
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