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Am J Physiol Heart Circ Physiol 281: H2159-H2167, 2001;
0363-6135/01 $5.00
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Vol. 281, Issue 5, H2159-H2167, November 2001

Role of Clminus current in endothelin-1-induced contraction in rabbit basilar artery

Yun Dai and John H. Zhang

Department of Neurosurgery, University of Mississippi Medical Center, Jackson, Mississippi 39216

Cl- efflux induces depolarization and contraction of smooth muscle cells. This study was undertaken to explore the role of Cl- channels in endothelin-1 (ET-1)-induced contraction in rabbit basilar artery. Male New Zealand White rabbits (n = 26), weighing 1.8-2.5 kg, were euthanized by an overdose of pentobarbital. The basilar arteries were removed for isometric tension recording. ET-1 produced a concentration-dependent contraction of the rabbit basilar artery in the normal Cl- Krebs-Henseleit bicarbonate buffer (123 mM Cl-). The ET-1-induced contraction was reduced by the following manipulations: 1) inhibition of Na+-K+-2Cl- cotransporter with bumetanide (3 × 10-5 and 10-4 M), 2) bicarbonate-free solution to disable Cl-/HCO<UP><SUB>3</SUB><SUP>−</SUP></UP> exchanger, and 3) preincubation of rings with the Cl- channel blockers niflumic acid, 5-nitro-2-(3-phenylpropylamino)benzoic acid, and indanyloxyacetic acid 94. The ET-1-induced contraction was enhanced by substitution of extracellular Cl- (10 mM) with methanesulfonic acid (113 mM). Cl- channels are involved in ET-1-induced contraction in the rabbit basilar artery.

Cl- channels; Na+-K+-2 Cl- cotransporter; Cl-/HCO<UP><SUB>3</SUB><SUP>−</SUP></UP> exchange


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