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Am J Physiol Heart Circ Physiol 281: H2218-H2225, 2001;
0363-6135/01 $5.00
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Vol. 281, Issue 5, H2218-H2225, November 2001

Role of endothelin ETB receptor activation in angiotensin II-induced hypertension: effects of salt intake

Jennifer R. Ballew and Gregory D. Fink

Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48823

We showed recently that endothelin (ET)A receptors are involved in the salt sensitivity of ANG II-induced hypertension. The objective of this current study was to characterize the role of endothelin ETB receptor activation in the same model. Male rats on fixed normal (2 meq/day) or high (6 meq/day) salt intake received a continuous intravenous infusion of ANG II or salt only for 15 days. During the middle 5 days of the infusion period, rats were given either the selective ETB receptor antagonist A-192621 or the nonselective endothelin receptor antagonist A-182086 (both at 24 mg · kg-1 · day-1 intra-arterially). Infusion of ANG II caused a greater rise in arterial pressure in rats on high-salt intake. The administration of A-192621 increased arterial pressure further in all rats. The chronic hypertensive effect of A-192621 was not significantly affected by salt intake or ANG II. The administration of A-182086 lowered arterial pressure chronically only in rats on normal salt intake receiving ANG II. Thus the salt sensitivity of ANG II-induced hypertension is not caused by changes in ETB receptor function.

blood pressure; salt-sensitive hypertension; kidney


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