| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
University Laboratory of Physiology, Oxford OX1 3PT, United Kingdom
We tested the hypothesis
that natriuretic peptide receptors (NPRs) that are coupled to cGMP
production act in a similar way to nitric oxide (NO) by enhancing
acetylcholine release and vagal-induced bradycardia. The effects of
enzyme inhibitors and channel blockers on the action of atrial
natriuretic peptide (ANP), brain-derived natriuretic peptide
(BNP), and C-type natriuretic peptide (CNP) were evaluated in isolated
guinea pig atrial-right vagal nerve preparations. RT-PCR confirmed the
presence NPR B and A receptor mRNA in guinea pig sinoatrial node
tissue. BNP and CNP significantly (P < 0.05) enhanced
the heart rate (HR) response to vagal nerve stimulation. CNP had no
effect on the HR response to carbamylcholine and facilitated the
release of [3H]acetylcholine during atrial field
stimulation. The particulate guanylyl cyclase-coupled receptor
antagonist HS-142-1, the phosphodiesterase 3 inhibitor milrinone,
the protein kinase A inhibitor H89, and the N-type calcium channel
blocker 
-conotoxin all blocked the effect of CNP on vagal-induced
bradycardia. Like NO, BNP and CNP facilitate vagal neurotransmission
and bradycardia. This may occur via a cGMP-PDE3-dependent pathway
increasing cAMP-PKA-dependent phosphorylation of presynaptic N-type
calcium channels.
nitric oxide; autonomic nervous system; acetylcholine; heart rate
This article has been cited by other articles:
|
|
 |
|
  E. Toader, R. M. McAllen, A. Cividjian, R. L. Woods, and L. Quintin Effect of systemic B-type natriuretic peptide on cardiac vagal motoneuron activity Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3465 - H3470. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-C. Yu, L.-H. Cao, and X.-L. Yang Modulation by Brain Natriuretic Peptide of GABA Receptors on Rat Retinal ON-Type Bipolar Cells J. Neurosci., January 11, 2006; 26(2): 696 - 707. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.M. Makikallio, T.H. Makikallio, J.T. Korpelainen, O. Vuolteenaho, J.M. Tapanainen, K. Ylitalo, K.A. Sotaniemi, H.V. Huikuri, and V.V. Myllyla Natriuretic Peptides and Mortality After Stroke Stroke, May 1, 2005; 36(5): 1016 - 1020. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. T. Ellinor, A. F. Low, K. K. Patton, M. A. Shea, and C. A. MacRae Discordant atrial natriuretic peptide and brain natriuretic peptide levels in lone atrial fibrillation J. Am. Coll. Cardiol., January 4, 2005; 45(1): 82 - 86. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Rose, A. E. Lomax, C. S. Kondo, M. B. Anand-Srivastava, and W. R. Giles Effects of C-type natriuretic peptide on ionic currents in mouse sinoatrial node: a role for the NPR-C receptor Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H1970 - H1977. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Wang, M. G. Larson, D. Levy, E. J. Benjamin, E. P. Leip, T. Omland, P. A. Wolf, and R. S. Vasan Plasma Natriuretic Peptide Levels and the Risk of Cardiovascular Events and Death N. Engl. J. Med., February 12, 2004; 350(7): 655 - 663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Rose, A. E. Lomax, and W. R. Giles Inhibition of L-type Ca2+ current by C-type natriuretic peptide in bullfrog atrial myocytes: an NPR-C-mediated effect Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2454 - H2462. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Herring, J. A.B. Zaman, and D. J. Paterson Particulate guanylyl cyclase and cholinergic control of cardiac excitability is site specific Cardiovasc Res, June 1, 2002; 54(3): 697 - 698. [Full Text] [PDF]
|
|
|
|
|
|
T. H. Hintze Prologue: Nitric oxide-hormones, metabolism, and function Am J Physiol Heart Circ Physiol, December 1, 2001; 281(6): H2253 - H2255. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
