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Am J Physiol Heart Circ Physiol 281: H2441-H2445, 2001;
0363-6135/01 $5.00
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Vol. 281, Issue 6, H2441-H2445, December 2001

Interleukin-1beta alters brown adipose tissue but not renal sympathetic nerve responses to hypothermia

Michael J. Kenney, Frank Blecha, Donald A. Morgan, and Richard J. Fels

Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas 66506; and Department of Internal Medicine, Cardiovascular Center, University of Iowa College of Medicine, Iowa City, Iowa 52242

Proinflammatory cytokines and acute physical stress influence sympathetic nerve discharge (SND). Because interleukin-1beta (IL-1beta ) produces physiological responses that require central neural integration and because the sympathetic nervous system mediates physiological responses to environmental stress, we hypothesized that IL-1beta modulates SND responses to acute physical stress. Therefore, this study examined the effects of IL-1beta (290 ng/kg iv) and mild hypothermia on renal and interscapular brown adipose tissue (IBAT) SND regulation in chloralose-anesthetized rats. IBAT SND did not change after IL-1beta administration but was significantly increased during acute mild hypothermia, which was induced 60 min after IL-1beta treatment. Renal SND was unchanged after IL-1beta administration and during hypothermia. Acute hypothermia, without prior IL-1beta administration, did not alter IBAT and renal SND. Increases in IBAT SND during sustained (120 min) hypothermia were significantly higher in IL-1beta -treated rats compared with saline-treated rats, whereas renal SND responses to sustained hypothermia did not differ among groups. Exposure to acute cold stress after sustained hypothermia produced greater increases in IBAT SND in IL-1beta -treated rats compared with saline-treated controls. These data suggest that IL-1beta alters IBAT SND responses to acute and sustained hypothermia.

sympathetic nerve activity; cytokines; chloralose; Sprague-Dawley rats


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