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Am J Physiol Heart Circ Physiol 281: H2645-H2653, 2001;
0363-6135/01 $5.00
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Vol. 281, Issue 6, H2645-H2653, December 2001

Postischemic mechanoenergetic inefficiency is related to contractile dysfunction and not altered metabolism

Christian Korvald1, Odd Petter Elvenes1, Ebrahim Aghajani1, Eivind S. P. Myhre2, and Truls Myrmel1

1 Department of Thoracic and Cardiovascular Surgery, University Hospital Tromsø, N-9038 Tromsø; and 2 Department of Medical Physiology, Institute of Medical Biology, University in Tromsø, N-9038 Tromsø, Norway

Mechanoenergetic inefficiency in postischemic nonnecrotic myocardium may partly be explained by an increased fatty acid (FA) oxidation rate. In the present study, left ventricular (LV) postischemic energy transfer was characterized in 10 intact anesthetized pigs. The LV was stunned by 11 brief left main coronary artery occlusions/reperfusions (20-min accumulated ischemia). Seven pigs served as time controls. The relationship between myocardial oxygen consumption (MVO2) and LV pressure-volume area (PVA) was assessed. [14C]glucose and [3H]oleate markers were used to discriminate between glucose and FA consumption. In stunned hearts, severe postischemic dysfunction was observed, and contractile efficiency was reduced (increased MVO2-PVA slope, P = 0.001). Unloaded (nonmechanical) MVO2 was not affected by ischemia. We observed only a small transient increase in FA preference and conclude that the contribution from increased FA utilization to postischemic mechanoenergetic inefficiency is insignificant. Disrupted postischemic chemical-to-mechanical energy transfer in vivo is, therefore, related to inefficient energy utilization in the contractile apparatus.

stunning; pig; ventricular function; energy metabolism; contractile efficiency


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