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-adrenergic stimulation
1 Department of Medical Surgical Nursing, University of Illinois at Chicago, Chicago 60612; and 2 Department of Physiology, Midwestern University, Downers Grove, Illinois 60515
The purpose of this study was to
investigate sex differences in the functional response of isolated rat
heart ventricular myocytes to 
-adrenergic stimulation and in
isoproterenol-stimulated signal transduction. Fractional shortening was
measured using a video edge-detection system in control- and
isoproterenol-stimulated myocytes that had been isolated from
weight-matched rats. Number and affinity of the -adrenergic
receptors and the L-type Ca2+ channel were measured in
ventricular cardiac membranes by radioligand binding studies. Control-
and isoproterenol-mediated alteration in Ca2+ current
density (ICa) was determined by patch clamping
and cellular cAMP content was determined by radioimmunoassay. Study
results demonstrate that female myocytes have higher Ca2+
channel density and greater ICa than male
myocytes. However, isoproterenol elicits a greater -adrenergic
receptor-mediated increase cell shortening, ICa
and cAMP production in male myocytes. Male myocytes were also found to
have a higher -adrenergic receptor density. These results suggest
that cardiac myocytes from male rats have an enhanced response to
-adrenergic stimulation due to augmented -adrenergic signaling
that results in a greater transsarcolemmal Ca2+ influx.
gender; calcium channel; calcium current; isoproterenol; heart
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